CCA tRNA nucleotidyltransferase (, ''CCA-adding enzyme'', ''tRNA adenylyltransferase'', ''tRNA CCA-pyrophosphorylase'', ''tRNA-nucleotidyltransferase'', ''transfer-RNA nucleotidyltransferase'', ''transfer ribonucleic acid nucleotidyl transferase'', ''CTP(ATP):tRNA nucleotidyltransferase'', ''transfer ribonucleate adenylyltransferase'', ''transfer ribonucleate adenyltransferase'', ''transfer RNA adenylyltransferase'', ''transfer ribonucleate nucleotidyltransferase'', ''ATP (CTP):tRNA nucleotidyltransferase'', ''ribonucleic cytidylic cytidylic adenylic pyrophosphorylase'', ''transfer ribonucleic adenylyl (cytidylyl) transferase'', ''transfer ribonucleic-terminal trinucleotide nucleotidyltransferase'', ''transfer ribonucleate cytidylyltransferase'', ''ribonucleic cytidylyltransferase'', ''-C-C-A pyrophosphorylase'', ''ATP(CTP)-tRNA nucleotidyltransferase'', ''tRNA adenylyl(cytidylyl)transferase'', ''CTP:tRNA cytidylyltransferase'') is an
enzyme
An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different mol ...
with
systematic name
A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature.
A semisystematic name or semitrivi ...
''CTP,CTP,ATP:tRNA cytidylyl,cytidylyl,adenylyltransferase''.
This enzyme
catalyses the following
chemical reaction
A chemical reaction is a process that leads to the chemistry, chemical transformation of one set of chemical substances to another. When chemical reactions occur, the atoms are rearranged and the reaction is accompanied by an Gibbs free energy, ...
: a tRNA precursor + 2 CTP + ATP
a tRNA with a 3' CCA end + 3
diphosphate
In chemistry, pyrophosphates are phosphorus oxyanions that contain two phosphorus atoms in a linkage. A number of pyrophosphate salts exist, such as disodium pyrophosphate () and tetrasodium pyrophosphate (), among others. Often pyrophosphate ...
(overall reaction)
:(1a) a tRNA precursor + CTP
a tRNA with a 3' cytidine end + diphosphate
:(1b) a tRNA with a 3' cytidine + CTP
a tRNA with a 3' CC end + diphosphate
:(1c) a tRNA with a 3' CC end + ATP
a tRNA with a 3' CCA end + diphosphate
The acylation of all tRNAs with an
amino acid
Amino acids are organic compounds that contain both amino and carboxylic acid functional groups. Although over 500 amino acids exist in nature, by far the most important are the 22 α-amino acids incorporated into proteins. Only these 22 a ...
occurs at the terminal
ribose
Ribose is a simple sugar and carbohydrate with molecular formula C5H10O5 and the linear-form composition H−(C=O)−(CHOH)4−H. The naturally occurring form, , is a component of the ribonucleotides from which RNA is built, and so this comp ...
of a 3' CCA sequence.
See also
*
TRNT1
tRNA-nucleotidyltransferase 1, is an enzyme that in humans is encoded by the ''TRNT1'' gene.
This enzyme adds the nucleotide sequence CCA to the 3' end of tRNA
Transfer ribonucleic acid (tRNA), formerly referred to as soluble ribonucleic acid (s ...
References
External links
*
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EC 2.7.7