Caspase recruitment domain-containing protein 10 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respon ...
in the
CARD-CC protein family that in humans is encoded by the ''CARD10''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
Function
The
caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein-protein homophilic interactions. CARDs induce nuclear factor kappa-B (
NF-κB
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular ...
; MIM 164011) activity through the IKK (e.g.,
IKBKB; MIM 603258) complex.
CARD9 (MIM 607212), CARD10,
CARD11 (MIM 607210), and
CARD14 (MIM 607211) interact with
BCL10 (MIM 603517) and are involved in NF-κB signaling complexes. Except for CARD9, these CARD proteins are members of the membrane-associated guanylate kinase (MAGUK) family.
upplied by OMIMref name="entrez" />
Interactions
CARD10 has been shown to
interact with
BCL10.
References
External links
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Further reading
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