Caspase recruitment domain-containing protein 10 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
in the
CARD-CC protein family that in humans is encoded by the ''CARD10''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
Function
The
caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in signaling through highly specific protein-protein homophilic interactions. CARDs induce nuclear factor kappa-B (
NF-κB
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a family of transcription factor protein complexes that controls transcription (genetics), transcription of DNA, cytokine production and cell survival. NF-κB is found i ...
; MIM 164011) activity through the IKK (e.g.,
IKBKB; MIM 603258) complex.
CARD9 (MIM 607212), CARD10,
CARD11 (MIM 607210), and
CARD14 (MIM 607211) interact with
BCL10 (MIM 603517) and are involved in NF-κB signaling complexes. Except for CARD9, these CARD proteins are members of the membrane-associated guanylate kinase (MAGUK) family.
upplied by OMIMref name="entrez" />
Interactions
CARD10 has been shown to
interact with
BCL10.
References
External links
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Further reading
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