Calcium-binding and coiled-coil domain-containing protein 2 is a
protein that in humans is encoded by the ''CALCOCO2''
gene.
The protein encoded by this gene is a subunit of nuclear domain 10 (ND10) bodies. ND10 bodies are nuclear domains appearing immunohistochemically as ten dots per nucleus. They are believed to be associated with the
nuclear matrix on the basis of their resistance to
nuclease
A nuclease (also archaically known as nucleodepolymerase or polynucleotidase) is an enzyme capable of cleaving the phosphodiester bonds between nucleotides of nucleic acids. Nucleases variously effect single and double stranded breaks in their ta ...
digestion and salt extraction. ND10 proteins are removed from the nucleus by
HSV-1 infection and may have a role in viral life cycles.
CALCOCO2 is an
autophagy
Autophagy (or autophagocytosis; from the Ancient Greek , , meaning "self-devouring" and , , meaning "hollow") is the natural, conserved degradation of the cell that removes unnecessary or dysfunctional components through a lysosome-dependent re ...
receptor, and loss of CALCOCO2 in human
beta cells has been linked to autophagy-mediated altered
insulin
Insulin (, from Latin ''insula'', 'island') is a peptide hormone produced by beta cells of the pancreatic islets encoded in humans by the ''INS'' gene. It is considered to be the main anabolic hormone of the body. It regulates the metabolism o ...
granule homeostasis. Thus, mutations in CALCOCO2 have been linked to
type 2 diabetes risk.
References
Further reading
*
*
*
*
*
*
*
*
*
External links
*
*
{{gene-17-stub