Calcium-dependent secretion activator 2 is a
protein that in humans is encoded by the ''CADPS2''
gene.
Function
This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium-binding proteins that regulate the
exocytosis
Exocytosis () is a form of active transport and bulk transport in which a cell transports molecules (e.g., neurotransmitters and proteins) out of the cell ('' exo-'' + ''cytosis''). As an active transport mechanism, exocytosis requires the use o ...
of
synaptic and
dense-core vesicle
Neuropeptides are chemical messengers made up of small chains of amino acids that are synthesized and released by neurons. Neuropeptides typically bind to G protein-coupled receptors (GPCRs) to modulate neural activity and other tissues like the ...
s in
neurons and
neuroendocrine cells.
Interactions
This gene interacts with
brain-derived neurotrophic factor.
Clinical significance
Cadps2 has been linked to
autism
The autism spectrum, often referred to as just autism or in the context of a professional diagnosis autism spectrum disorder (ASD) or autism spectrum condition (ASC), is a neurodevelopmental condition (or conditions) characterized by difficulti ...
and is in the 7q autism susceptibility locus (AUTS1). However, the finding of aberrant CADPS2 splicing was not found to be significant in another study.
A
knockout mouse model was found to have autistic-like characteristics.
CADPS2 has been linked to human and mouse brain structure in two large genomic studies.
References
External links
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Further reading
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