Cell adhesion molecule 1 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that, in humans, is encoded by the ''CADM1''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
Interactions
Cell adhesion molecule 1 has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization advocating for the legal and human rights of children with intersex traits. The organization was founded in 2006 and fo ...
with
EPB41L3
Band 4.1-like protein 3 is a protein that in humans is encoded by the ''EPB41L3'' gene.
Interactions
EPB41L3 has been shown to interact with YWHAB, YWHAH
14-3-3 protein eta also referred to as 14-3-3η is a protein that in humans is encoded ...
.
Association studies
Genome-wide association studies
In genomics, a genome-wide association study (GWA study, or GWAS), is an observational study of a genome-wide set of genetic variants in different individuals to see if any variant is associated with a trait. GWA studies typically focus on assoc ...
identified an association between
body mass index
Body mass index (BMI) is a value derived from the mass (Mass versus weight, weight) and height of a person. The BMI is defined as the human body weight, body mass divided by the square (algebra), square of the human height, body height, and is ...
and two loci near the ''CADM1'' and ''CADM2'' gene.
Experimental results of another study showed that obese mice had an over expression of both ''CADM1'' and ''CADM2'' genes, and that loss of ''CADM1'' protected mice from obesity, promoting a negative energy balance and weight loss.
Furthermore, a 2019
GWAS GWAS may refer to:
*Genome-wide association study, study of mutations' correlations with disease or other phenotypic expressions
*''gwas'', a Welsh term for a valet
* Great Western Ambulance Service, the ambulance service serving Somerset, Gloucest ...
study revealed an association between
Anorexia nervosa
Anorexia nervosa (AN), often referred to simply as anorexia, is an eating disorder characterized by Calorie restriction, food restriction, body image disturbance, fear of gaining weight, and an overpowering desire to be thin.
Individuals wit ...
and ''CADM1''.
In the brain, this genes mediate synaptic assembly, and mutations in ''CADM1'' are also associated with
Autistic spectrum disorder
Autism, also known as autism spectrum disorder (ASD), is a neurodevelopmental disorder characterized by differences or difficulties in social communication and interaction, a preference for predictability and routine, sensory processing di ...
.
See also
*
Cell adhesion molecule
Cell adhesion molecules (CAMs) are a subset of cell surface proteins that are involved in the binding of cells with other cells or with the extracellular matrix (ECM), in a process called cell adhesion. In essence, CAMs help cells stick to each ...
*
Nectin
Nectins and Nectin-like molecules (Necl) are families of cellular adhesion molecules involved in Calcium in biology, Ca2+-independent cellular adhesion.
Nectins are ubiquitously expressed and have adhesive roles in a wide range of tissues such as ...
References
Further reading
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{{Cell adhesion molecules
Genes mutated in mice