Voltage-dependent calcium channel subunit alpha-2/delta-1 is a
protein that in humans is encoded by the ''CACNA2D1''
gene.
This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional
splice variants of this gene have been observed, but have not been thoroughly characterized.
Gabapentinoids
alpha2/delta proteins are believed to be the molecular target of the
gabapentinoids
gabapentin and
pregabalin, which are used to treat
epilepsy and
neuropathic pain.
See also
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Voltage-dependent calcium channel
References
Further reading
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External links
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Ion channels
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