C. N. Hugh Long
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Cyril Norman Hugh Long (June 19, 1901 – July 6, 1970) was an English-American
biochemist Biochemists are scientists who are trained in biochemistry. They study chemical processes and chemical transformations in living organisms. Biochemists study DNA, proteins and cell parts. The word "biochemist" is a portmanteau of "biological che ...
and academic administrator. He was
Sterling Professor Sterling Professor, the highest academic rank at Yale University, is awarded to a tenured faculty member considered the best in his or her field. It is akin to the rank of university professor at other universities. The appointment, made by the ...
of
physiological chemistry Biochemistry or biological chemistry is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology an ...
at
Yale University Yale University is a Private university, private research university in New Haven, Connecticut. Established in 1701 as the Collegiate School, it is the List of Colonial Colleges, third-oldest institution of higher education in the United Sta ...
for 31 years during the middle part of the 20th century.


Background

Cyril Long was born in
Burton, Nettleton, Wiltshire Burton is a small village with 103 households (2014) in the Cotswolds Area of Outstanding Natural Beauty in Wiltshire, England. Kelly's 1915 Directory of Wiltshire identifies Burton as the most important part of the parish of Nettleton. It is ab ...
, the first of two sons of John Edward Long and Rose Fanny Long, née Langward. As a young man, he did not plan to study to become a scientist. He instead experimented with diverse areas such as perfume making and working with wood. Long devoted much of his time to literature and history. As a child he enjoyed playing soccer and cricket and many times his father needed to remind him to come back home to study. He always performed well during his school years and was ranked among the best of his graduating class. He appeared to have a natural talent for chemistry and once said, "I was attracted from an early age to chemistry, largely by my own fortunate contact in an English school with a science master ... whose ways of teaching it was so effective that a large number of his students have become scientists". Long studied
organic chemistry Organic chemistry is a subdiscipline within chemistry involving the science, scientific study of the structure, properties, and reactions of organic compounds and organic materials, i.e., matter in its various forms that contain carbon atoms.Clay ...
under Robert Robinson and
Arthur Lapworth Arthur Lapworth FRS (10 October 1872 – 5 April 1941) was a Scottish chemist. He was born in Galashiels, Scotland, the son of geologist Charles Lapworth, and educated at St Andrew's and King Edward's School, Birmingham. He graduated in chemist ...
at the
University of Manchester The University of Manchester is a public university, public research university in Manchester, England. The main campus is south of Manchester city centre, Manchester City Centre on Wilmslow Road, Oxford Road. The university owns and operates majo ...
, where he received his BSc. Shortly after his graduation in 1921, he began assisting Nobel laureate
A. V. Hill Archibald Vivian Hill (26 September 1886 – 3 June 1977), known as A. V. Hill, was a British physiologist, one of the founders of the diverse disciplines of biophysics and operations research. He shared the 1922 Nobel Prize in Physiology or Me ...
in his work on the biophysics of muscle contraction. After working for two years at
University College London , mottoeng = Let all come who by merit deserve the most reward , established = , type = Public research university , endowment = £143 million (2020) , budget = � ...
, Long sailed on 4 September 1925 on the
RMS Aurania RMS ''Aurania'' can refer to any of three ships originally owned and operated by the Cunard Line Cunard () is a British shipping and cruise line based at Carnival House at Southampton, England, operated by Carnival UK and owned by Carniv ...
from Liverpool to Quebec, to work in
Montreal Montreal ( ; officially Montréal, ) is the second-most populous city in Canada and most populous city in the Canadian province of Quebec. Founded in 1642 as '' Ville-Marie'', or "City of Mary", it is named after Mount Royal, the triple- ...
with Jonathan Meakins at
McGill University McGill University (french: link=no, Université McGill) is an English-language public research university located in Montreal, Quebec, Canada. Founded in 1821 by royal charter granted by King George IV,Frost, Stanley Brice. ''McGill Universit ...
; he received his
M.D. Doctor of Medicine (abbreviated M.D., from the Latin ''Medicinae Doctor'') is a medical degree, the meaning of which varies between different jurisdictions. In the United States, and some other countries, the M.D. denotes a professional degree. T ...
there in 1928. He served as director of the George S. Cox Medical Research Institute, a diabetes research center at the
University of Pennsylvania The University of Pennsylvania (also known as Penn or UPenn) is a private research university in Philadelphia. It is the fourth-oldest institution of higher education in the United States and is ranked among the highest-regarded universit ...
. In 1936, Long moved to the
School of Medicine A medical school is a tertiary educational institution, or part of such an institution, that teaches medicine, and awards a professional degree for physicians. Such medical degrees include the Bachelor of Medicine, Bachelor of Surgery (MBBS, MB ...
. At Yale, he was Director of the Division of Biological Sciences (1939–42), Dean of the School of Medicine (1947–52), and Chair of Physiology (1951–64). In the 1930s and 1940s Long and Abraham White worked together in the Yale Medical Center. As a result of their and Hubert R Catchpole's work in 1937 they isolated bovine prolactin, the first of the
protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respon ...
pituitary In vertebrate anatomy, the pituitary gland, or hypophysis, is an endocrine gland, about the size of a chickpea and weighing, on average, in humans. It is a protrusion off the bottom of the hypothalamus at the base of the brain. The hyp ...
hormones A hormone (from the Greek participle , "setting in motion") is a class of signaling molecules in multicellular organisms that are sent to distant organs by complex biological processes to regulate physiology and behavior. Hormones are required fo ...
to be obtained in pure
crystal A crystal or crystalline solid is a solid material whose constituents (such as atoms, molecules, or ions) are arranged in a highly ordered microscopic structure, forming a crystal lattice that extends in all directions. In addition, macr ...
line form. Later, they isolated different hormones, and later characterized and
sequenced In genetics and biochemistry, sequencing means to determine the primary structure (sometimes incorrectly called the primary sequence) of an unbranched biopolymer. Sequencing results in a symbolic linear depiction known as a sequence which succi ...
many of them, greatly contributing to modern
biochemistry Biochemistry or biological chemistry is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology ...
. Long mainly worked with the hormones of the pituitary gland and adrenal extracts of the
metabolism Metabolism (, from el, μεταβολή ''metabolē'', "change") is the set of life-sustaining chemical reactions in organisms. The three main functions of metabolism are: the conversion of the energy in food to energy available to run c ...
; his major research goal was to find a cure for
diabetes Diabetes, also known as diabetes mellitus, is a group of metabolic disorders characterized by a high blood sugar level (hyperglycemia) over a prolonged period of time. Symptoms often include frequent urination, increased thirst and increased ...
. Long was elected to the United States
National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Nat ...
in 1948 and a member of both the
American Philosophical Society The American Philosophical Society (APS), founded in 1743 in Philadelphia, is a scholarly organization that promotes knowledge in the sciences and humanities through research, professional meetings, publications, library resources, and communi ...
and the
American Academy of Arts and Sciences The American Academy of Arts and Sciences (abbreviation: AAA&S) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, ...
in 1949. Long married Hilda Gertrude Jarman in
Kerrisdale, Vancouver Kerrisdale is a neighbourhood in the city of Vancouver, British Columbia, Canada. Kerrisdale is a neighbourhood located in Vancouver's west side. It features a mix of newer houses and older bungalows as well as various low and mid-rise rental a ...
on 28 July 1928.,British Columbia, Canada, Marriage Index, 1872-1935 and they had two daughters: Diana Elizabeth Long (Diana Long Hall), a historian of science and medicine, and Barbara Rosemary Long. Long was naturalised on 1 July 1942, and Hilda on 19 November 1948, while they were living at 100 Old Farm Road,
Hamden, Connecticut Hamden is a town in New Haven County, Connecticut, United States. The town's nickname is "The Land of the Sleeping Giant". The population was 61,169 at the 2020 census. History The peaceful tribe of Quinnipiacs were the first residents of the ...
. Cyril Norman Hugh Long died on 6 July 1970, aged 69. Hilda died on 16 October 1988, aged 76. They are both buried at
Grove Street Cemetery Grove Street Cemetery or Grove Street Burial Ground is a cemetery in New Haven, Connecticut, that is surrounded by the Yale University campus. It was organized in 1796 as the New Haven Burying Ground and incorporated in October 1797 to replace the ...
, New Haven, Connecticut.


References

{{DEFAULTSORT:Long, Cyril Norman Hugh 1901 births 1970 deaths Yale School of Medicine faculty People from Wiltshire Yale Sterling Professors British emigrants to the United States Members of the American Philosophical Society