In
genetics
Genetics is the study of genes, genetic variation, and heredity in organisms.Hartl D, Jones E (2005) It is an important branch in biology because heredity is vital to organisms' evolution. Gregor Mendel, a Moravian Augustinian friar worki ...
, rs1800955 (also written as C-521T and -521C/T) is a
single nucleotide polymorphism (SNP).
It is located in the
promoter region of the ''
DRD4'' gene.
This gene codes for the
dopamine receptor
Dopamine receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS). Dopamine receptors activate different effectors through not only G-protein coupling, but also signaling through diffe ...
D4.
Due to the
dopamine hypothesis of schizophrenia the SNP has been investigated for link to
schizophrenia
Schizophrenia is a mental disorder characterized by continuous or relapsing episodes of psychosis. Major symptoms include hallucinations (typically hearing voices), delusions, and disorganized thinking. Other symptoms include social wi ...
, and it may be slightly associated with this disorder.
The SNP has been investigated with respect to
novelty seeking, — a
personality trait
In psychology, trait theory (also called dispositional theory) is an approach to the study of human personality. Trait theorists are primarily interested in the measurement of ''traits'', which can be defined as habitual patterns of behaviour, t ...
that may be measured with the
Temperament and Character Inventory The Temperament and Character Inventory (TCI) is an inventory for personality traits devised by Cloninger et al.
It is closely related to and an outgrowth of the Tridimensional Personality Questionnaire (TPQ),
and it has also been related to the d ...
.
A 2008
meta-analysis
A meta-analysis is a statistical analysis that combines the results of multiple scientific studies. Meta-analyses can be performed when there are multiple scientific studies addressing the same question, with each individual study reporting m ...
indicates a possible association between novelty seeking and C-521T though rather small.
References
Other
Table 4from "The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes"
SNPs on chromosome 11
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