BxPC-3 (BxPC3) is a human
pancreatic cancer
Pancreatic cancer arises when cell (biology), cells in the pancreas, a glandular organ behind the stomach, begin to multiply out of control and form a Neoplasm, mass. These cancerous cells have the malignant, ability to invade other parts of t ...
cell line
An immortalised cell line is a population of cells from a multicellular organism which would normally not proliferate indefinitely but, due to mutation, have evaded normal cellular senescence and instead can keep undergoing division. The cell ...
used in the study of pancreatic
adenocarcinoma
Adenocarcinoma (; plural adenocarcinomas or adenocarcinomata ) (AC) is a type of cancerous tumor that can occur in several parts of the body. It is defined as neoplasia of epithelial tissue that has glandular origin, glandular characteristics, or ...
s and treatments thereof.
BxPC-3 cells were derived from a 61-year-old female in 1986, and were confirmed to be tumorigenic in athymic nude mice, with moderate
differentiation. The cells produce
mucin, and exhibit an epithelial morphology. BxPC-3 cells lack a
KRAS mutation, though it is commonly found in pancreatic cancers. BcPC-3 cells, along with JoPaca-1 cells, have high expression of cancer
stem cell marker Stem cell markers are genes and their protein products used by scientists to isolate and identify stem cell
In multicellular organisms, stem cells are undifferentiated or partially differentiated cells that can differentiate into various types ...
s.
BxPC-3 has been used in tumorigenicity studies, pancreatic cancer therapy research, and other biomedical applications. The cells have been additionally studied for their
phenotypic
In genetics, the phenotype () is the set of observable characteristics or traits of an organism. The term covers the organism's morphology or physical form and structure, its developmental processes, its biochemical and physiological proper ...
and
genotypic
The genotype of an organism is its complete set of genetic material. Genotype can also be used to refer to the alleles or variants an individual carries in a particular gene or genetic location. The number of alleles an individual can have in a ...
properties as they can be applied to pancreatic cancer drug development; in particular, BxPC-3 cells have high expression of the angiogenic factors
IL-8,
VEGF
Vascular endothelial growth factor (VEGF, ), originally known as vascular permeability factor (VPF), is a signal protein produced by many cells that stimulates the formation of blood vessels. To be specific, VEGF is a sub-family of growth factors, ...
, and
PGE2
Prostaglandin E2 (PGE2), also known as dinoprostone, is a naturally occurring prostaglandin with oxytocic properties that is used as a medication. Dinoprostone is used in labor induction, bleeding after delivery, termination of pregnancy, an ...
, which can serve as potential drug targets.
See also
*
DU145
DU145 (DU-145) is a human prostate cancer
Prostate cancer is cancer of the prostate. Prostate cancer is the second most common cancerous tumor worldwide and is the fifth leading cause of cancer-related mortality among men. The prostate is a gla ...
*
MIA PaCa-2
MIA PaCa-2 is a human pancreatic cancer cell line used extensively in pancreatic cancer research and therapy development.
In 1977, MIA PaCa-2 cells were derived from the carcinoma of a 65-year-old male.
The cells exhibit CK5.6, AE1/AE3, E-cad ...
*
PANC-1 PANC-1 is a human pancreatic cancer cell line isolated from a pancreatic carcinoma of Ductal cells, ductal cell origin.
PANC-1 was derived from the tissue of a 56-year-old male. The cells can metastasis, metastasize but have poor differentiation a ...
References
{{Reflist
External links
Cellosaurus entry for BxPC-3
Human cell lines