Butaperazine (Repoise, Tyrylen) is a typical antipsychotic of the phenothiazine class. It was approved in 1967, and possibly discontinued in the 1980s.

Synthesis

2-Butyrylphenothiazine 5244-91-1(1) is the requisite starting material for carrying out the procedure. It is prepared in a manner that is synonymous with the method used in the propiomazine and propiopromazine already discussed. The 1-(γ-chloropropyl)-4-methylpiperazine 04-16-5(2) is prepared in the conventional way from alkylating

1-methylpiperazine ''N''-Methylpiperazine is a heterocyclic organic compound. Uses ''N''-Methylpiperazine is a common building block used in organic synthesis. For example, ''N''-methylpiperazine is used in the manufacture of various pharmaceutical drugs includin ...

and

1-Bromo-3-chloropropane 1-Bromo-3-chloropropane is an organohalogen compound with the formula Br(CH2)3Cl. It is a colorless liquid, produced by free-radical addition of hydrogen bromide to allyl chloride. It is used as an alkylating agent to install the –(CH2)3Cl an ...

. Sodamide is used to extract the 10-H thereby facilitating the nucleophilic substitution reaction. And completing the instalment of the sidechain.

References

Phenothiazines Piperazines Aromatic ketones Typical antipsychotics Propyl compounds {{nervous-system-drug-stub

Synthesis

See also

References