Broadband Acoustic Resonance Dissolution Spectroscopy

Broadband acoustic resonance dissolution spectroscopy (BARDS) is a technique in analytical chemistry. Developed in the late 2000s,D. Fitzpatrick, 2009, "Instrumentation and analytical techniques suitable for broadband acoustic resonance dissolution spectroscopy", ''US Patent'', US8813566B2 it involves the analysis of the changes in sound frequency generated when a solute dissolves in a solvent, by harnessing the hot chocolate effect.

The technique is partly based on the solubility difference of gas in pure solvents and in solutions. The dissolution of a compound in a pure solvent results in the generation of gas bubbles in the solvent, due to the lowering of gas solubility in the resulting solution, as well as the introduction of gases with the solute. The presence of these gas bubbles increases the compressibility of the solution, thereby lowering the velocity of sound in the solution. This effect can be monitored by means of the frequency change of acoustic resonances that are mechanically produced in the solvent.

Principles of the BARDS response

Water is approximately 800 times more dense than air. However, air is approximately 15,000 times more compressible than water. The velocity of sound, ''υ'', in a homogeneous liquid or gas is given by the following equation:
:$\upsilon = \frac$

where ρ is the mass density and K the compressibility of the gas or liquid. K is given as:
:$K = \frac$

where V is the volume of the medium, and dV is the volume decrease due to the pressure increase dp of the sound wave. When water is filled with air bubbles, the fluid density is essentially the density of water, and the air will contribute significantly to the compressibility. Crawford derived the relationship between fractional bubble volume and sound velocity in water, and hence the sound frequency in water, given as.Frank S. Crawford, May 1982, "The hot chocolate effect", ''American Journal of Physics'', Volume 50, Issue 5, pp. 398–404, doi:10.1119/1.13080 (Abstract only)
:$= = ^$

where ''υ_w'' and ''υ'' are the velocities of sound in pure and bubble-filled water, respectively, ''f_w'' and ''f'' are the frequencies of sound in pure and bubble-filled water, respectively, V_a is defined as the fractional volume occupied by gas bubbles, and ''α'' is a constant. When the solvent is water and the gas is air, the value of ''α'' is 1.49 × 10⁴.

The effect of changes in solution density and solution compressibility are additive and reinforce the phenomenon, causing a significant decrease in the velocity of sound and, therefore, a significant decrease in the frequency of sound passing through an aerated solution.

Applications

BARDS has significant potential as an analytical technique. Applications researched so far include:

* Batch consistency analysisD. Fitzpatrick ''et al.'', March 2012, "Principles and Applications of Broadband Acoustic Resonance Dissolution Spectroscopy (BARDS): A Sound Approach for the Analysis of Compounds", ''Analytical Chemistry'', Volume 84, Issue 5, pp. 2202–2210, doi:10.1021/ac202509s
* Blend uniformity analysisD. Fitzpatrick ''et al.'', 2012, "Blend uniformity analysis of pharmaceutical products by Broadband Acoustic Resonance Dissolution Spectroscopy (BARDS)", ''International Journal of Pharmaceutics'', Volume 438, Issue 1–2, pp. 134–139, doi:10.1016/j.ijpharm.2012.07.073
* Polymorph and pseudopolymorph discrimination
* Monitoring of supersaturation of solutions and rates of outgassingD. Fitzpatrick ''et al.'', 2013, "The relationship between dissolution, gas oversaturation and outgassing of solutions determined by Broadband Acoustic Resonance Dissolution Spectroscopy (BARDS)", ''Analyst'', Volume 138, Issue 17, pp. 5005–5010, doi:10.1039/C3AN36838F

See also

*The hot chocolate effect, the physical phenomenon on which the technique is based.
* Acoustic resonance spectroscopy

References

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Spectroscopy