Brendan John Frey FRSC (born 29 August 1968) is a Canadian computer scientist, entrepreneur, and engineer. He is Founder and CEO of Deep Genomics, Cofounder of the Vector Institute for Artificial Intelligence and Professor of Engineering and Medicine at the University of Toronto. Frey is a pioneer in the development of
machine learning
Machine learning (ML) is a field of study in artificial intelligence concerned with the development and study of Computational statistics, statistical algorithms that can learn from data and generalise to unseen data, and thus perform Task ( ...
and
artificial intelligence
Artificial intelligence (AI) is the capability of computer, computational systems to perform tasks typically associated with human intelligence, such as learning, reasoning, problem-solving, perception, and decision-making. It is a field of re ...
methods, their use in accurately determining the consequences of genetic
mutations
In biology, a mutation is an alteration in the nucleic acid sequence of the genome of an organism, virus, or extrachromosomal DNA. Viral genomes contain either DNA or RNA. Mutations result from errors during DNA or viral replication, mitosi ...
, and in designing
medications
Medication (also called medicament, medicine, pharmaceutical drug, medicinal product, medicinal drug or simply drug) is a drug used to medical diagnosis, diagnose, cure, treat, or preventive medicine, prevent disease. Drug therapy (pharmaco ...
that can slow, stop or reverse the progression of disease.
As far back as 1995, Frey co-invented one of the first
deep learning
Deep learning is a subset of machine learning that focuses on utilizing multilayered neural networks to perform tasks such as classification, regression, and representation learning. The field takes inspiration from biological neuroscience a ...
methods, called the wake-sleep algorithm, the affinity propagation algorithm for clustering and data summarization, and the factor graph notation for probability models. In the late 1990s, Frey was a leading researcher in the areas of
computer vision
Computer vision tasks include methods for image sensor, acquiring, Image processing, processing, Image analysis, analyzing, and understanding digital images, and extraction of high-dimensional data from the real world in order to produce numerical ...
,
speech recognition
Speech recognition is an interdisciplinary subfield of computer science and computational linguistics that develops methodologies and technologies that enable the recognition and translation of spoken language into text by computers. It is also ...
, and
digital communications
Data communication, including data transmission and data reception, is the transfer of data, signal transmission, transmitted and received over a Point-to-point (telecommunications), point-to-point or point-to-multipoint communication chann ...
.
Education
Frey studied computer engineering and physics at the
University of Calgary
{{Infobox university
, name = University of Calgary
, image = University of Calgary coat of arms without motto scroll.svg
, image_size = 150px
, caption = Coat of arms
, former ...
(BSc 1990) and the
University of Manitoba
The University of Manitoba (U of M, UManitoba, or UM) is a public research university in Winnipeg, Manitoba, Canada. Founded in 1877, it is the first university of Western Canada. Both by total student enrolment and campus area, the University of ...
(MSc 1993), and then studied
neural network
A neural network is a group of interconnected units called neurons that send signals to one another. Neurons can be either biological cells or signal pathways. While individual neurons are simple, many of them together in a network can perfor ...
University of Toronto
The University of Toronto (UToronto or U of T) is a public university, public research university whose main campus is located on the grounds that surround Queen's Park (Toronto), Queen's Park in Toronto, Ontario, Canada. It was founded by ...
Following his undergraduate studies, Frey worked as a junior research scientist at Bell-Northern Research from 1990 to 1991. After completing his postdoctoral studies at the University of Illinois at Urbana-Champaign, Frey was an assistant professor in the Department of Computer Science at the
University of Waterloo
The University of Waterloo (UWaterloo, UW, or Waterloo) is a Public university, public research university located in Waterloo, Ontario, Canada. The main campus is on of land adjacent to uptown Waterloo and Waterloo Park. The university also op ...
Microsoft Research
Microsoft Research (MSR) is the research subsidiary of Microsoft. It was created in 1991 by Richard Rashid, Bill Gates and Nathan Myhrvold with the intent to advance state-of-the-art computing and solve difficult world problems through technologi ...
Cambridge University
The University of Cambridge is a Public university, public collegiate university, collegiate research university in Cambridge, England. Founded in 1209, the University of Cambridge is the List of oldest universities in continuous operation, wo ...
. Between 2001 and 2014, Frey consulted for several groups at
Microsoft Research
Microsoft Research (MSR) is the research subsidiary of Microsoft. It was created in 1991 by Richard Rashid, Bill Gates and Nathan Myhrvold with the intent to advance state-of-the-art computing and solve difficult world problems through technologi ...
and acted as a member of its Technical Advisory Board.
In 2002, a personal crisis led Frey to face the fact that there was a tragic gap between our ability to measure a patient's mutations and our ability to understand and treat the consequences. Recognizing that biology is too complex for humans to understand, that in the decades to come there would be an
exponential growth
Exponential growth occurs when a quantity grows as an exponential function of time. The quantity grows at a rate directly proportional to its present size. For example, when it is 3 times as big as it is now, it will be growing 3 times as fast ...
in biology data, and that
machine learning
Machine learning (ML) is a field of study in artificial intelligence concerned with the development and study of Computational statistics, statistical algorithms that can learn from data and generalise to unseen data, and thus perform Task ( ...
is the best technology we have for discovering relationships in large datasets, Frey set out to build machine learning systems that could accurately predict genome and cell biology.
Frey’s group pioneered much of the early work in the field and over the next 15 years published more papers in leading-edge journals than any other academic or industrial research lab.
In 2015, Frey founded Deep Genomics, with the goal of building a company that can produce effective and safe genetic medicines more rapidly and with a higher rate of success than was previously possible.
The company has received 240 million dollars in funding to date from leading Bay Area investors, including the backers of SpaceX and Tesla.