Bodroux–Chichibabin Aldehyde Synthesis on:
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The Bodroux–Chichibabin aldehyde synthesis is a 
chemical reaction
A chemical reaction is a process that leads to the chemical transformation of one set of chemical substances to another. Classically, chemical reactions encompass changes that only involve the positions of electrons in the forming and break ...
whereby a Grignard reagent is converted to an aldehyde
In organic chemistry, an aldehyde () is an organic compound containing a functional group with the structure . The functional group itself (without the "R" side chain) can be referred to as an aldehyde but can also be classified as a formyl group ...
one carbon longer.
:
Reaction of a Grignard reagent with triethyl orthoformate gives an acetal
In organic chemistry, an acetal is a functional group with the connectivity . Here, the R groups can be organic fragments (a carbon atom, with arbitrary other atoms attached to that) or hydrogen, while the R' groups must be organic fragment ...
, which can be hydrolyzed
Hydrolysis (; ) is any chemical reaction in which a molecule of water breaks one or more chemical bonds. The term is used broadly for substitution, elimination, and solvation reactions in which water is the nucleophile.
Biological hydrolysis ...
to an aldehyde. For example, the synthesis of n- hexanal:
:
See also
* Bouveault aldehyde synthesisReferences