Blue Mass
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Blue mass (also known as blue pill or ''pilula hydrargyri'') was the name of a mercury-based medical treatment for
syphilis Syphilis () is a sexually transmitted infection caused by the bacterium ''Treponema pallidum'' subspecies ''pallidum''. The signs and symptoms depend on the stage it presents: primary, secondary, latent syphilis, latent or tertiary. The prim ...
common from the 17th to the 19th centuries. The oldest formula is ascribed to one
Barbarossa Barbarossa, a name meaning "red beard" in Italian, primarily refers to: * Frederick Barbarossa (1122–1190), Holy Roman Emperor * Hayreddin Barbarossa (c. 1478–1546), Ottoman admiral * Operation Barbarossa, the Axis invasion of the Soviet Uni ...
, in a letter to
Francis I of France Francis I (; ; 12 September 1494 – 31 March 1547) was King of France from 1515 until his death in 1547. He was the son of Charles, Count of Angoulême, and Louise of Savoy. He succeeded his first cousin once removed and father-in-law Louis&nbs ...
.


Description

Blue mass was used as a specific treatment for syphilis from at least the late 17th century to the early 18th. Blue mass was recommended as a remedy for such widely varied complaints as
tuberculosis Tuberculosis (TB), also known colloquially as the "white death", or historically as consumption, is a contagious disease usually caused by ''Mycobacterium tuberculosis'' (MTB) bacteria. Tuberculosis generally affects the lungs, but it can al ...
,
constipation Constipation is a bowel dysfunction that makes bowel movements infrequent or hard to pass. The Human feces, stool is often hard and dry. Other symptoms may include abdominal pain, bloating, and feeling as if one has not completely passed the ...
,
toothache Toothaches, also known as dental pain or tooth pain,Segen JC. (2002). ''McGraw-Hill Concise Dictionary of Modern Medicine''. The McGraw-Hill Companies. is pain in the teeth or their supporting structures, caused by dental diseases or referred ...
, parasitic infestations, and the pains of
childbirth Childbirth, also known as labour, parturition and delivery, is the completion of pregnancy, where one or more Fetus, fetuses exits the Womb, internal environment of the mother via vaginal delivery or caesarean section and becomes a newborn to ...
. The Edinburgh New Dispensatory (1789) instructs the making as follows: "Pilula ex Hydrargyro ondon(Quicksilver-pills). Take of Purified quicksilver, Extract of liquorice, having the consistence of honey, of each two drams, Liquorice, finally powdered, one dram. Rub the quicksilver with the extract of liquorice until the globules disappear; then, add the liquorice-powder, mix them together." A combination of blue mass and a mixture called the common black draught was a standard cure for
constipation Constipation is a bowel dysfunction that makes bowel movements infrequent or hard to pass. The Human feces, stool is often hard and dry. Other symptoms may include abdominal pain, bloating, and feeling as if one has not completely passed the ...
in early 19th century
England England is a Countries of the United Kingdom, country that is part of the United Kingdom. It is located on the island of Great Britain, of which it covers about 62%, and List of islands of England, more than 100 smaller adjacent islands. It ...
and elsewhere. It was particularly valued on
ship A ship is a large watercraft, vessel that travels the world's oceans and other Waterway, navigable waterways, carrying cargo or passengers, or in support of specialized missions, such as defense, research and fishing. Ships are generally disti ...
s of the
Royal Navy The Royal Navy (RN) is the naval warfare force of the United Kingdom. It is a component of His Majesty's Naval Service, and its officers hold their commissions from the King of the United Kingdom, King. Although warships were used by Kingdom ...
, where
sailor A sailor, seaman, mariner, or seafarer is a person who works aboard a watercraft as part of its crew, and may work in any one of a number of different fields that are related to the operation and maintenance of a ship. While the term ''sailor'' ...
s and officers were constrained to eat rock-hard salted beef and
pork Pork is the culinary name for the meat of the pig (''Sus domesticus''). It is the most commonly consumed meat worldwide, with evidence of pig animal husbandry, husbandry dating back to 8000–9000 BCE. Pork is eaten both freshly cooke ...
, old stale biscuits (
hardtack Hardtack (or hard tack) is a type of dense Cracker (food), cracker made from flour, water, and sometimes salt. Hardtack is inexpensive and long-lasting. It is used for sustenance in the absence of perishable foods, commonly during long sea voyage ...
), and very little
fruit In botany, a fruit is the seed-bearing structure in flowering plants (angiosperms) that is formed from the ovary after flowering. Fruits are the means by which angiosperms disseminate their seeds. Edible fruits in particular have long propaga ...
,
fiber Fiber (spelled fibre in British English; from ) is a natural or artificial substance that is significantly longer than it is wide. Fibers are often used in the manufacture of other materials. The strongest engineering materials often inco ...
, or other fresh food once they were at sea for an extended period. It was a magistral preparation, compounded by pharmacists themselves based on their own recipes or on one of several widespread recipes. It was sold in the form of blue or gray
pill Pill or The Pill may refer to: Drugs * Pill (pharmacy), referring to anything small for a specific dose of medicine * "The Pill", a general nickname for the combined oral contraceptive pill Film and television * ''The Pill'' (film), a 2011 fil ...
s, or
syrup In cooking, syrup (less commonly sirup; from ; , beverage, wine and ) is a condiment that is a thick, viscous liquid consisting primarily of a Solution (chemistry), solution of sugar in water, containing a large amount of dissolved sugars but ...
. Its name probably derives from the use of blue
dye Juan de Guillebon, better known by his stage name DyE, is a French musician. He is known for the music video of the single "Fantasy Fantasy is a genre of speculative fiction that involves supernatural or Magic (supernatural), magical ele ...
or blue
chalk Chalk is a soft, white, porous, sedimentary carbonate rock. It is a form of limestone composed of the mineral calcite and originally formed deep under the sea by the compression of microscopic plankton that had settled to the sea floor. Ch ...
(used as a buffer) in some formulations. The ingredients of blue mass varied, as each
pharmacist A pharmacist, also known as a chemist in English in the Commonwealth of Nations, Commonwealth English, is a healthcare professional who is knowledgeable about preparation, mechanism of action, clinical usage and legislation of medications in ...
prepared it himself, but they all included mercury in elemental or compound form (often as mercury chloride, also known as
calomel Calomel is a Mercury element, mercury chloride mineral with Chemical formula, formula Hg2Cl2 (see mercury(I) chloride). It was used as a medicine from the 16th to early 20th century, despite frequently causing mercury poisoning in patients. The ...
). One recipe of the period for blue mass syrup included:King's American Dispensatory, 1898.
/ref> * 33% mercury (measured by weight) * 5%
licorice Liquorice (Commonwealth English) or licorice (American English; see spelling differences; ) is the common name of ''Glycyrrhiza glabra'', a flowering plant of the bean family Fabaceae, from the root of which a sweet, aromatic flavouring is ...
* 25% ''Althaea'' (possibly
hollyhock ''Alcea'' is a genus of over 80 species of flowering plants in the mallow family Malvaceae, commonly known as the hollyhocks. They are native to Asia and Europe. The single species of hollyhock from the Americas, the Iliamna rivularis, streamban ...
or
marshmallow Marshmallow (, ) is a confectionery made from sugar, water and gelatin whipped to a solid-but-soft consistency. It is used as a filling in baking or molded into shapes and coated with corn starch. This sugar confection is inspired by a medicina ...
) * 3%
glycerol Glycerol () is a simple triol compound. It is a colorless, odorless, sweet-tasting, viscous liquid. The glycerol backbone is found in lipids known as glycerides. It is also widely used as a sweetener in the food industry and as a humectant in pha ...
* 34%
rose A rose is either a woody perennial plant, perennial flowering plant of the genus ''Rosa'' (), in the family Rosaceae (), or the flower it bears. There are over three hundred Rose species, species and Garden roses, tens of thousands of cultivar ...
honey Honey is a sweet and viscous substance made by several species of bees, the best-known of which are honey bees. Honey is made and stored to nourish bee colonies. Bees produce honey by gathering and then refining the sugary secretions of pl ...
Blue pills were produced by substituting
milk sugar Lactose is a disaccharide composed of galactose and glucose and has the molecular formula C12H22O11. Lactose makes up around 2–8% of milk (by mass). The name comes from ( gen. ), the Latin word for milk, plus the suffix '' -ose'' used t ...
and
rose oil Rose oil (rose otto, attar of rose, attar of roses, or rose essence) is an essential oil that is extracted from the petals of various types of rose. ''Rose ottos'' are extracted through steam distillation, while ''rose absolutes'' are obtained t ...
for the glycerol and rose honey. Pills contained one
grain A grain is a small, hard, dry fruit (caryopsis) – with or without an attached husk, hull layer – harvested for human or animal consumption. A grain crop is a grain-producing plant. The two main types of commercial grain crops are cereals and ...
(64.8 milligrams) of mercury.


Toxicity

Mercury is now known to be toxic, and ingestion of mercury leads to
mercury poisoning Mercury poisoning is a type of metal poisoning due to exposure to mercury. Symptoms depend upon the type, dose, method, and duration of exposure. They may include muscle weakness, poor coordination, numbness in the hands and feet, skin rashe ...
, a form of heavy-metal poisoning. While mercury is still used in compound form in some types of medicines and for other purposes, blue mass contained excessive amounts of the metal: a typical daily dose of two or three blue mass pills represented ingestion of more than one hundred times the daily limits set by the Environmental Protection Agency in the
United States The United States of America (USA), also known as the United States (U.S.) or America, is a country primarily located in North America. It is a federal republic of 50 U.S. state, states and a federal capital district, Washington, D.C. The 48 ...
today.


Use by Abraham Lincoln

For several years before his election to the presidency,
Abraham Lincoln Abraham Lincoln (February 12, 1809 – April 15, 1865) was the 16th president of the United States, serving from 1861 until Assassination of Abraham Lincoln, his assassination in 1865. He led the United States through the American Civil War ...
is known to have taken blue-mass pills for treatment of chronic
melancholia Melancholia or melancholy (from ',Burton, Bk. I, p. 147 meaning black bile) is a concept found throughout ancient, medieval, and premodern medicine in Europe that describes a condition characterized by markedly depressed mood, bodily complain ...
. It's been reported that during this time, Lincoln was known to have experienced neurological symptoms, including insomnia, tremor and rage attacks, which suggests he may have been suffering from mercury poisoning. However, a few months after his inauguration, Lincoln reportedly stopped taking the medication because he perceived the pills made him "cross". In 2001, a study led by renowned public-health investigator
Norbert Hirschhorn Norbert Hirschhorn (born 1938) is an Austrian-born American public health physician. He was one of the inventors and developers of the life-saving method called oral rehydration therapy for adults and children suffering fluid loss from cholera and ...
recreated a typical formulation, concluding that the quantity of blue mass that Lincoln likely took would have delivered "a daily dose of mercury exceeding the current Environmental Protection Agency safety standard by nearly 9000 times," which may have adversely affected his health.


References


External links


Blue Mass






{{DEFAULTSORT:Blue Mass Mercury (element) Withdrawn drugs