Blood Stasis
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Blood stasis (also blood stagnation and blood stasis syndrome) (BS) is a concept in
traditional Chinese medicine Traditional Chinese medicine (TCM) is an alternative medicine, alternative medical practice drawn from traditional medicine in China. A large share of its claims are pseudoscientific, with the majority of treatments having no robust evidence ...
(TCM), described as a slowing or pooling of the blood due to a disruption of heart qi. Blood stasis is also described by practitioners of TCM in terms of yin deficiency, qi deficiency and qi stagnation. For non-practitioners of TCM it is sometimes explained in terms of
hematological Hematology ( spelled haematology in British English) is the branch of medicine concerned with the study of the cause, prognosis, treatment, and prevention of diseases related to blood. It involves treating diseases that affect the production ...
disorders such as
hemorrhage Bleeding, hemorrhage, haemorrhage or blood loss, is blood escaping from the circulatory system from damaged blood vessels. Bleeding can occur internally, or externally either through a natural opening such as the mouth, nose, ear, urethra, ...
, congestion,
thrombosis Thrombosis () is the formation of a Thrombus, blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system. When a blood vessel (a vein or an artery) is injured, the body uses platelets (thrombocytes) and fib ...
or local
ischemia Ischemia or ischaemia is a restriction in blood supply to any tissue, muscle group, or organ of the body, causing a shortage of oxygen that is needed for cellular metabolism (to keep tissue alive). Ischemia is generally caused by problems ...
, and in terms of tissue changes. TCM practitioners believe it is an important underlying pathology of many disease processes despite the fact that objective, consistent methods for measuring the presence of blood stasis syndrome are not readily available. Blood stasis is associated with justifications for acupuncture and herbal treatments.


History

Practitioners of TCM believe that descriptions of BS can be traced back to the '' Inner Canon of Huangdi'' (about 200 B.C.E. in China) and understanding of it evolved with the practice of traditional East Asia medicine (TEAM), however there were no standard diagnostic criteria until the 1980s. Despite this the diagnosis of BS was applied to both chronic internal diseases and external injuries with treatment involving "activating blood circulation to dissipate blood stasis." Standard diagnostic criteria for BS were first established in 1982 in
China China, officially the People's Republic of China (PRC), is a country in East Asia. With population of China, a population exceeding 1.4 billion, it is the list of countries by population (United Nations), second-most populous country after ...
by the ''Specialized Committee of "activating blood circulation"'' and in
Japan Japan is an island country in East Asia. Located in the Pacific Ocean off the northeast coast of the Asia, Asian mainland, it is bordered on the west by the Sea of Japan and extends from the Sea of Okhotsk in the north to the East China Sea ...
by Terasawa ''et al'' in 1983. These criteria were revised in 1988 in China with the "diagnostic criteria of Blood-stasis symptom-complex" and Terasawa revised the diagnostic criteria in Japan in 1989. Since 1989 research conducted by TCM practitioners on BS and its treatment has increased and some of this research has shown
correlation In statistics, correlation or dependence is any statistical relationship, whether causal or not, between two random variables or bivariate data. Although in the broadest sense, "correlation" may indicate any type of association, in statistics ...
s between BS and abnormal coagulation function,
inflammation Inflammation (from ) is part of the biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. The five cardinal signs are heat, pain, redness, swelling, and loss of function (Latin ''calor'', '' ...
, and accelerated red blood cell senescence. This increase in research has also highlighted the inconsistencies of BS diagnostic criteria. Amongst practitioners of TCM and related fields covered by the general term ''traditional East Asia medicine'' (TEAM) there is a large body of research on blood stasis. A survey conducted in 2014 amongst practitioners of
traditional Korean medicine Traditional Korean medicine (known in North Korea as Koryo medicine) refers to the forms of traditional medicine practiced in Korea. History Korean medical traditions originated in ancient and prehistoric times and can be traced back as far as ...
found that more than half of the respondents still had difficulties with the diagnosis of BS because "objective measurement methods were not readily available" despite, or perhaps because, the diagnostic criteria for BS is regularly revised. East Asian nations encourage and reward the use of TCM for all ailments, including
COVID-19 Coronavirus disease 2019 (COVID-19) is a contagious disease caused by the coronavirus SARS-CoV-2. In January 2020, the disease spread worldwide, resulting in the COVID-19 pandemic. The symptoms of COVID‑19 can vary but often include fever ...
. As an example, pharmacologist Li Lianda received a National Science and Technology Progress Award in 2018 from the
People's Republic of China China, officially the People's Republic of China (PRC), is a country in East Asia. With population of China, a population exceeding 1.4 billion, it is the list of countries by population (United Nations), second-most populous country after ...
for his work on the scientific explanation of BS and the basic laws and mechanism of action of "activating blood circulation and removing blood stasis". Notwithstanding the 'criticisms' below, there is a considerable degree of overlap between the presence of fibrinaloid microclots in blood and the various diseases considered to involve blood stasis syndrome. As a result, beneficial effects (cited therein) have regularly been shown using suitable cocktails of herbs used in
Chinese Herbal Medicine Chinese herbology () is the theory of traditional Chinese herbal therapy, which accounts for the majority of treatments in traditional Chinese medicine (TCM). A ''Nature'' editorial described TCM as "fraught with pseudoscience", and said that t ...
and the equivalent Japanese
Kampo Kampo or , often known simply as , is the study of traditional medicine in Japan following its introduction, beginning in the 7th century. It was adapted and modified to suit Japanese culture and traditions. Traditional Japanese medicine us ...
, where blood stasis is known as Oketsu.


Criticism

Blood stasis, as defined within TCM, is a pseudo-scientific concept and uses other pseudo-scientific or mystical concepts such as qi, meridians, acupuncture, yin and yang as part of its description. The concept of BS is also based on incorrect knowledge regarding human physiology, in particular the liver. "The Liver stores Blood ... when a person moves, Blood goes to the channels, when at rest it goes to the Liver" and "Blood volume problems indirectly influences our resistance to external pathogenic factors. If this Liver function is normal, the skin and muscles will be well nourished by Blood and be able to resist attacks of exterior pathogenic factors." Mark Crislip, infectious disease doctor, referred to these quotes as "gibberish" in a 2015 Science-Based Medicine article. Crislip also mentions that "Many researchers are trying to shoehorn BS into vascular diseases such as angina and lipid disorders." He referred to the characteristic symptoms of BS "such as pain in a fixed position, nyctalgia, dark-purple coloring of the tongue or face, infraorbital darkness, sublingual varicosis, blood spots under the skin or tongue, or an astringent pulse" and the attempt to link BS with conditions such as "ischemic heart disease, cerebral vascular accident, diabetes mellitus, chronic gastritis, chronic renal failure, chronic hepatitis, trauma, and dysmenorrhea" as nonsense. He stated that:


Purported mechanism of action

In TCM, the
spleen The spleen (, from Ancient Greek '' σπλήν'', splḗn) is an organ (biology), organ found in almost all vertebrates. Similar in structure to a large lymph node, it acts primarily as a blood filter. The spleen plays important roles in reg ...
and
kidney In humans, the kidneys are two reddish-brown bean-shaped blood-filtering organ (anatomy), organs that are a multilobar, multipapillary form of mammalian kidneys, usually without signs of external lobulation. They are located on the left and rig ...
s govern the movement and transformation of qi and fluid and these organs cooperate with each other to participate in the metabolism of water. A functional disorder of the spleen or kidneys would lead to qi stagnation and blood stasis. Some causes of blood stasis are believed to include: too little nutrients, too much sugar, too little sleep, too much alcohol, lack of movement, too much movement (over-training), emotional stress, trauma, heat in the body, and cold in the body. Recommendations to improve blood flow include not eating while stressed, not eating too fast, breathing, focusing on gratitude while eating, not overeating, avoiding cold foods, avoiding damp foods (peanuts, soy and dairy), eating more of eggplants, cayenne, garlic, ginger, turmeric, shiitake, saffron, vinegar, etc. Treatments include acupuncture, cupping, electrical acupuncture and herbal remedies. A recent review suggests that insoluble 'fibrinaloid' microclots may be a cause, consistent with the utility of the herbal formula XueFu Zhuyu for treating blood stasis.


References


External links


NCI Dictionary of Cancer Terms - blood stasis as defined in TCM
{{Authority control Traditional Chinese medicine