Bisulepin is strong and relatively selective

antihistamine Antihistamines are drugs which treat allergic rhinitis, common cold, influenza, and other allergies. Typically, people take antihistamines as an inexpensive, generic (not patented) drug that can be bought without a prescription and provides ...

( H₁ antagonist) with

hypnotic A hypnotic (from Ancient Greek, Greek ''Hypnos'', sleep), also known as a somnifacient or soporific, and commonly known as sleeping pills, are a class of psychoactive drugs whose primary function is to sleep induction, induce sleep and to trea ...

antiadrenergic An adrenergic antagonist is a drug that inhibits the function of adrenergic receptors. There are five adrenergic receptors, which are divided into two groups. The first group of receptors are the beta (β) adrenergic receptors. There are Beta-1 ad ...

and very weak

anticholinergic Anticholinergics (anticholinergic agents) are substances that block the action of the acetylcholine (ACh) neurotransmitter at synapses in the central nervous system, central and peripheral nervous system. These agents inhibit the parasympatheti ...

and

antiserotonergic A serotonin antagonist, or serotonin receptor antagonist, is a drug used to inhibit the action of serotonin and serotonergic drugs at serotonin (5-HT) receptors. Types 5-HT2A antagonists Antagonists of the 5-HT2A receptor are sometimes used ...

effects. Bisulepin is marketed in the

Czech Republic The Czech Republic, also known as Czechia, and historically known as Bohemia, is a landlocked country in Central Europe. The country is bordered by Austria to the south, Germany to the west, Poland to the northeast, and Slovakia to the south ...

and

Slovakia Slovakia, officially the Slovak Republic, is a landlocked country in Central Europe. It is bordered by Poland to the north, Ukraine to the east, Hungary to the south, Austria to the west, and the Czech Republic to the northwest. Slovakia's m ...

under the trademark Dithiaden as tablets and injections. The registered active form is the ''trans''- (i.e. ''E''-) isomer.Pharmacopoea Bohemoslovenica 4 (1987), vol. 2, p. 132 states that Bisulepinium chloratum (bisulepinium chloride) is ''trans''- -(4,9-dihydro-thieno[2,3-''c''2">,3-''c''.html" ;"title="-(4,9-dihydro-thieno[2,3-''c''">-(4,9-dihydro-thieno[2,3-''c''2enzithiepin-4-yliden)propyl]dimethylamoniumchlorid (Czech). The ''cis''- isomer is considered as an impurity, max. amount 2.0 %.

References

External links

Chemical data for bisulepin hydrochloride
{{Antihistamines, state=expanded H1 receptor antagonists Thiepines Thiophenes Antihistamines

See also

References

External links