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Birdsey Renshaw (October 10, 1911 – November 23, 1948) was an American electrophysiologist and neuroscientist. He is known for his 1941 discovery of the eponymous
Renshaw cell Renshaw cells are inhibitory interneurons found in the gray matter of the spinal cord, and are associated in two ways with an alpha motor neuron. * They receive an excitatory collateral from the alpha neuron's axon as they emerge from the motor ...
s and the Renshaw inhibition (recurrent inhibition), which is a negative feedback mechanism associated with the Renshaw cell action.


Biography

In 1936 he graduated with an M.D. from
Harvard Medical School Harvard Medical School (HMS) is the medical school of Harvard University and is located in the Longwood Medical and Academic Area, Longwood Medical Area in Boston, Massachusetts. Founded in 1782, HMS is the third oldest medical school in the Un ...
and then joined Alexander Forbes's neurophysiological research team in Harvard Medical School's physiology department. There he learned how to record cerebral action potentials using
amplifier An amplifier, electronic amplifier or (informally) amp is an electronic device that can increase the magnitude of a signal (a time-varying voltage or current). It is a two-port electronic circuit that uses electric power from a power su ...
s and
cathode-ray tube A cathode-ray tube (CRT) is a vacuum tube containing one or more electron guns, which emit electron beams that are manipulated to display images on a phosphorescent screen. The images may represent electrical waveforms on an oscilloscope, a ...
s. He developed microelectrodes from ultra-clean Pyrex pipettes and applied the microelectrodes to make extracellular recordings of action potentials found in the mammalian hippocampus and cortex. In 1938 he received his PhD with thesis ''The Electrical Potentials Recorded in the Brain with Microelectrodes''. In 1938, after receiving his PhD. he joined
Herbert Spencer Gasser Herbert Spencer Gasser (July 5, 1888 – May 11, 1963) was an American physiologist, and recipient of the Nobel Prize for Physiology or Medicine in 1944 for his work with action potentials in nerve fibers while on the faculty of Washington Unive ...
's group at the Rockefeller Institute for Medical Research (now named
Rockefeller University The Rockefeller University is a Private university, private Medical research, biomedical Research university, research and graduate-only university in New York City, New York. It focuses primarily on the biological and medical sciences and pro ...
). The research group included David Lloyd (1911–1985),
Rafael Lorente de Nó Rafael Lorente de Nó (April 8, 1902 – April 2, 1990) was a Spanish neuroscientist who advanced the scientific understanding of the nervous system with his seminal research. He was a member of the National Academy of Sciences. The National Academ ...
, and Harry Grundfest. In 1948 Renshaw died of
polio Poliomyelitis ( ), commonly shortened to polio, is an infectious disease caused by the poliovirus. Approximately 75% of cases are asymptomatic; mild symptoms which can occur include sore throat and fever; in a proportion of cases more severe ...
within three days of the onset of symptoms. In 1954 Eccles, Fatt, and Koketsu used intracellular recording to confirm Renshaw's findings and introduced the term "Renshaw cell".


Family

Birdsey Renshaw's mother was Laura Birdsey Renshaw (1878–1930) and his father was Raemer Rex Renshaw (1880–1938), a professor of organic chemistry at New York University and, during WW I, a U.S. Army captain in the Chemical Warfare Service. Late on the night of September 23, 1938, Professor Raemer Rex Renshaw and his second wife died after falling nineteen stories from their
Tudor City Tudor City is an apartment complex on the East Side (Manhattan), East Side of Manhattan in New York City, bordering the Turtle Bay, Manhattan, Turtle Bay and Murray Hill, Manhattan, Murray Hill neighborhoods. It lies on a low cliff east of Sec ...
apartment at 45
Prospect Place Prospect Place, also known as The Trinway Mansion and Prospect Place Estate, is a 29-room mansion built by abolitionist George Willison Adams (G. W. Adams) in Trinway, Ohio, just north of Dresden in 1856. Today, it is the home of the non-pro ...
in Manhattan. In August 1939 in
Holyoke, Massachusetts Holyoke is a city in Hampden County, Massachusetts, United States, that lies between the western bank of the Connecticut River and the Mount Tom Range. As of the 2020 United States census, 2020 census, the city had a population of 38,247. Loca ...
, Birdsey Renshaw married Janet Card Hayes, who graduated from
Mount Holyoke College Mount Holyoke College is a Private college, private Women's colleges in the United States, women's Liberal arts colleges in the United States, liberal arts college in South Hadley, Massachusetts, United States. It is the oldest member of the h ...
. She had two brothers and two sisters. The younger of her two brothers was Samuel Perkins Hayes Jr. (1910–2002), who was a social psychologist, a consultant to the
Peace Corps The Peace Corps is an Independent agency of the U.S. government, independent agency and program of the United States government that trains and deploys volunteers to communities in partner countries around the world. It was established in Marc ...
from 1961 to 1969, and president of the
Foreign Policy Association The Foreign Policy Association (FPA, formerly known as the League of Free Nations Association) is an American non-profit foreign policy organization. According to the FPA, the organization aims to spread global awareness and understanding of US f ...
until 1975. Birdsey and Janet Renshaw had two sons, Thomas Hayes Renshaw and Bruce Birdsey Renshaw.


Selected publications

* * * * * * * * * * * * * * * * * *


References


External links

* {{DEFAULTSORT:Renshaw, Birdsey 1911 births 1948 deaths American neuroscientists American physiologists Electrophysiologists Neurophysiologists Harvard Medical School alumni Rockefeller University people People from Middletown, Connecticut