BioNumerics is a

bioinformatics Bioinformatics () is an interdisciplinary field of science that develops methods and Bioinformatics software, software tools for understanding biological data, especially when the data sets are large and complex. Bioinformatics uses biology, ...

desktop software application that manages

microbiological Microbiology () is the scientific study of microorganisms, those being of unicellular (single-celled), multicellular (consisting of complex cells), or acellular (lacking cells). Microbiology encompasses numerous sub-disciplines including virol ...

data. It is developed by Applied Maths NV, a bioMérieux company.

History

BioNumerics was first released in 1998. PulseNet, a network run by the

Centers for Disease Control and Prevention The Centers for Disease Control and Prevention (CDC) is the National public health institutes, national public health agency of the United States. It is a Federal agencies of the United States, United States federal agency under the United S ...

(CDC), uses BioNumerics to compare

pulsed field gel electrophoresis Pulsed-field gel electrophoresis (PFGE) is a technique used for the separation of large DNA molecules by applying an electric field that periodically changes direction to a gel matrix. Unlike standard agarose gel electrophoresis, which can separa ...

(PFGE) patterns and whole genome sequences from different bacterial strains. CaliciNet, an outbreak surveillance network for noroviruses, is another example of a network which uses BioNumerics to submit

norovirus Norovirus, also known as Norwalk virus and sometimes referred to as the winter vomiting disease, is the most common cause of gastroenteritis. Infection is characterized by non-bloody diarrhea, vomiting, and stomach pain. Fever or headaches may ...

sequences and basic epidemiologic information to a central database.

Features

The basis of BioNumerics is a database consisting of entries. The entries correspond to the individual organisms or samples under study and are characterized by a unique key and by a number of user-defined information fields. Each entry in a

database In computing, a database is an organized collection of data or a type of data store based on the use of a database management system (DBMS), the software that interacts with end users, applications, and the database itself to capture and a ...

 may be characterized by one or more experiments that can be linked easily to the entry. In BioNumerics, experiments are divided in seven classes:  fingerprints, spectra, characters, sequences, sequence read sets, trend data and matrices. Examples of BioNumerics applications are whole genome Multi Locus Sequence Typing (wgMLST), whole genome

Single Nucleotide Polymorphisms In genetics and bioinformatics, a single-nucleotide polymorphism (SNP ; plural SNPs ) is a germline substitution of a single nucleotide at a specific position in the genome. Although certain definitions require the substitution to be present in ...

(wgSNP), genome comparison, identification based on MALDI-TOF Mass Spectrometry, PFGE typing,

Amplified Fragment Length Polymorphism Amplified fragment length polymorphism (AFLP-PCR or AFLP) is a PCR-based tool used in genetics research, DNA fingerprinting, and in the practice of genetic engineering. Developed in the early 1990s by Pieter Vos, AFLP uses restriction enzymes t ...

(AFLP) typing, sequence-based typing of viruses,

antibiotic resistance Antimicrobial resistance (AMR or AR) occurs when microbes evolve mechanisms that protect them from antimicrobials, which are drugs used to treat infections. This resistance affects all classes of microbes, including bacteria (antibiotic resis ...

profiling and functional genotyping.

References

External links

Applied Maths’ official websiteScientific articles using BioNumerics
{{DEFAULTSORT:BIONUMERICS Bioinformatics software