Bevenopran (

INN Inns are generally establishments or buildings where travelers can seek lodging, and usually, food and drink. Inns are typically located in the country or along a highway. Before the advent of motorized transportation, they also provided accomm ...

USAN 280px, "Samguk Sagi" Book 04. Silla's Records. In 512, Usan-guk（于山國）was Ulleungdo（鬱陵島） Usan-guk, or the State of Usan, occupied Ulleung-do and the adjacent islands during the Korean Three Kingdoms period. According to t ...

) (former developmental code names CB-5945, ADL-5945, MK-2402, OpRA III) is a

peripherally acting μ-opioid receptor antagonist Peripherally acting μ-opioid receptor Opioid Receptor antagonist, antagonists (PAMORAs) are a class of chemical compounds that are used to reverse adverse effects caused by opioids interacting with receptor (biochemistry), receptors outside the ce ...

that also acts on

δ-opioid receptor The δ-opioid receptor, also known as delta opioid receptor or simply delta receptor, abbreviated DOR or DOP, is an inhibitory 7-transmembrane G-protein coupled receptor coupled to the G protein Gi alpha subunit, Gi/G0 and has enkephalins as it ...

s and was under development by

Cubist Pharmaceuticals Cubist Pharmaceuticals, Inc. was an American biopharmaceutical company that targeted pathogens like MRSA. . The company employed 638 people, mostly in Lexington, Massachusetts. On 8 December 2014, Merck & Co. acquired Cubist for $102 per share ...

for the treatment of chronic

opioid Opioids are a class of Drug, drugs that derive from, or mimic, natural substances found in the Papaver somniferum, opium poppy plant. Opioids work on opioid receptors in the brain and other organs to produce a variety of morphine-like effects, ...

-induced

constipation Constipation is a bowel dysfunction that makes bowel movements infrequent or hard to pass. The Human feces, stool is often hard and dry. Other symptoms may include abdominal pain, bloating, and feeling as if one has not completely passed the ...

. It reached phase III

clinical trial Clinical trials are prospective biomedical or behavioral research studies on human subject research, human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel v ...

s for this indication before being discontinued.Bevenopran
/ref>

References

Secondary amines Carboxamides Drugs acting on the gastrointestinal system and metabolism Laxatives Mu-opioid receptor antagonists Peripherally selective drugs Pyrazines {{gastrointestinal-drug-stub

See also

References