Sir Bernard Katz, FRS (; 26 March 1911 – 20 April 2003) was a German-born

British British may refer to: Peoples, culture, and language * British people, nationals or natives of the United Kingdom, British Overseas Territories and Crown Dependencies. * British national identity, the characteristics of British people and culture ...

physician and

biophysicist Biophysics is an interdisciplinary science that applies approaches and methods traditionally used in physics to study biological phenomena. Biophysics covers all scales of biological organization, from molecular to organismic and populations ...

, noted for his work on

nerve A nerve is an enclosed, cable-like bundle of nerve fibers (called axons). Nerves have historically been considered the basic units of the peripheral nervous system. A nerve provides a common pathway for the Electrochemistry, electrochemical nerv ...

physiology Physiology (; ) is the science, scientific study of function (biology), functions and mechanism (biology), mechanisms in a life, living system. As a branches of science, subdiscipline of biology, physiology focuses on how organisms, organ syst ...

; specifically, for his work on

synaptic transmission Neurotransmission (Latin: ''transmissio'' "passage, crossing" from ''transmittere'' "send, let through") is the process by which signaling molecules called neurotransmitters are released by the axon terminal of a neuron (the presynaptic neuron) ...

at the nerve-muscle junction. He shared the

Nobel Prize in physiology or medicine The Nobel Prize in Physiology or Medicine () is awarded yearly by the Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, acco ...

in 1970 with

Julius Axelrod Julius Axelrod (May 30, 1912 – December 29, 2004) was an American biochemist. He won a share of the Nobel Prize in Physiology or Medicine in 1970 along with Bernard Katz and Ulf von Euler. The Nobel Committee honored him for his work on the ...

and

Ulf von Euler Ulf Svante von Euler (7 February 1905 – 9 March 1983) was a Swedish physiologist and pharmacologist. He shared the Nobel Prize in Physiology or Medicine in 1970 for his work on neurotransmitters. Life Ulf Svante von Euler-Chelpin was born in S ...

. He was made a

Knight Bachelor The title of Knight Bachelor is the basic rank granted to a man who has been knighted by the monarch but not inducted as a member of one of the organised Order of chivalry, orders of chivalry; it is a part of the Orders, decorations, and medals ...

in 1969.

Life and career

Katz was born in

Leipzig Leipzig (, ; ; Upper Saxon: ; ) is the most populous city in the States of Germany, German state of Saxony. The city has a population of 628,718 inhabitants as of 2023. It is the List of cities in Germany by population, eighth-largest city in Ge ...

, Germany, to a

Jewish Jews (, , ), or the Jewish people, are an ethnoreligious group and nation, originating from the Israelites of History of ancient Israel and Judah, ancient Israel and Judah. They also traditionally adhere to Judaism. Jewish ethnicity, rel ...

family originally from Russia, the son of Eugenie (Rabinowitz) and Max Katz, a fur merchant. He was educated at the Albert Gymnasium in that city from 1921 to 1929 and went on to study medicine at the

University of Leipzig Leipzig University (), in Leipzig in Saxony, Germany, is one of the world's oldest universities and the second-oldest university (by consecutive years of existence) in Germany. The university was founded on 2 December 1409 by Frederick I, Electo ...

. He graduated in 1934 and fled to Britain in February 1935. Katz went to work at

University College London University College London (Trade name, branded as UCL) is a Public university, public research university in London, England. It is a Member institutions of the University of London, member institution of the Federal university, federal Uni ...

, initially under the tutelage of

Archibald Vivian Hill Archibald Vivian Hill (26 September 1886 – 3 June 1977), better known to friends and colleagues as A. V. Hill, was a British physiologist, one of the founders of the diverse disciplines of biophysics and operations research. He shared the 192 ...

. He finished his PhD in 1938 and won a

Carnegie Fellowship The Carnegie Corporation of New York is a philanthropic fund established by Andrew Carnegie in 1911 to support education programs across the United States, and later the world. Since its founding, the Carnegie Corporation has endowed or othe ...

to study with

John Carew Eccles Sir John Carew Eccles (27 January 1903 – 2 May 1997) was an Australian neurophysiologist and philosopher who won the 1963 Nobel Prize in Physiology or Medicine for his work on the synapse. He shared the prize with Andrew Huxley and Alan Lloy ...

at the Kanematsu Institute of

Sydney Medical School The University of Sydney School of Medicine, also known as Sydney Medical School (SMS) is the graduate medical school of the University of Sydney. Established in 1856, it is the first medical school in Australia. In 2018, Sydney Medical School j ...

. During this time, both he and Eccles gave research lectures at the

University of Sydney The University of Sydney (USYD) is a public university, public research university in Sydney, Australia. Founded in 1850, it is the oldest university in both Australia and Oceania. One of Australia's six sandstone universities, it was one of the ...

. He obtained British nationality in 1941 and joined the

Royal Australian Air Force The Royal Australian Air Force (RAAF) is the principal Air force, aerial warfare force of Australia, a part of the Australian Defence Force (ADF) along with the Royal Australian Navy and the Australian Army. Constitutionally the Governor-Gener ...

in 1942. He spent the war in the Pacific as a

radar Radar is a system that uses radio waves to determine the distance ('' ranging''), direction ( azimuth and elevation angles), and radial velocity of objects relative to the site. It is a radiodetermination method used to detect and track ...

officer and in 1946 was invited back to UCL as an assistant director by

Hill A hill is a landform that extends above the surrounding terrain. It often has a distinct summit, and is usually applied to peaks which are above elevation compared to the relative landmass, though not as prominent as Mountain, mountains. Hills ...

. For three years until 1949, the Katz family lived with

and his wife

Margaret Margaret is a feminine given name, which means "pearl". It is of Latin origin, via Ancient Greek and ultimately from Iranian languages, Old Iranian. It has been an English language, English name since the 11th century, and remained popular thro ...

in the top flat of their house in

Highgate Highgate is a suburban area of N postcode area, north London in the London Borough of Camden, London Boroughs of Camden, London Borough of Islington, Islington and London Borough of Haringey, Haringey. The area is at the north-eastern corner ...

. Back in England he also worked with the 1963 Nobel prize winners

Alan Hodgkin Sir Alan Lloyd Hodgkin (5 February 1914 – 20 December 1998) was an English physiology, physiologist and biophysics, biophysicist who shared the 1963 Nobel Prize in Physiology or Medicine with Andrew Huxley and John Eccles (neurophysiologist) ...

and

Andrew Huxley Sir Andrew Fielding Huxley (22 November 191730 May 2012) was an English physiologist and biophysicist. He was born into the prominent Huxley family. After leaving Westminster School in central London, he went to Trinity College, Cambridge, ...

. Katz was made a professor at UCL in 1952 and head of the Biophysics Department; he was elected a Fellow of the Royal Society (FRS) in 1952. He stayed as head of Biophysics until 1978 when he became emeritus professor. Katz married Marguerite Penly in 1945. He died in London on 20 April 2003, at the age of 92. His son Jonathan is

Public Orator The Public Orator is a traditional official post at universities, especially in the United Kingdom. The holder of this office acts as the voice of the university on public occasions. The position at Oxford University dates from 1564. The Public O ...

of The

University of Oxford The University of Oxford is a collegiate university, collegiate research university in Oxford, England. There is evidence of teaching as early as 1096, making it the oldest university in the English-speaking world and the List of oldest un ...

Research

His research uncovered fundamental properties of

synapse In the nervous system, a synapse is a structure that allows a neuron (or nerve cell) to pass an electrical or chemical signal to another neuron or a target effector cell. Synapses can be classified as either chemical or electrical, depending o ...

s, the junctions across which nerve cells signal to each other and to other types of cells. By the 1950s, he was studying the biochemistry and action of

acetylcholine Acetylcholine (ACh) is an organic compound that functions in the brain and body of many types of animals (including humans) as a neurotransmitter. Its name is derived from its chemical structure: it is an ester of acetic acid and choline. Par ...

, a

signalling molecule In biology, cell signaling (cell signalling in British English) is the process by which a cell interacts with itself, other cells, and the environment. Cell signaling is a fundamental property of all cellular life in both prokaryotes and eukaryot ...

found in synapses linking

motor neuron A motor neuron (or motoneuron), also known as efferent neuron is a neuron whose cell body is located in the motor cortex, brainstem or the spinal cord, and whose axon (fiber) projects to the spinal cord or outside of the spinal cord to directly o ...

s to

muscle Muscle is a soft tissue, one of the four basic types of animal tissue. There are three types of muscle tissue in vertebrates: skeletal muscle, cardiac muscle, and smooth muscle. Muscle tissue gives skeletal muscles the ability to muscle contra ...

s,The Release of Neural Transmitter Substances (The Sherrington Lectures X), Charles C Thomas Publisher, Springfield (Illinois) 1969, pp. 60 used to stimulate contraction. Katz won the Nobel for his discovery with

Paul Fatt Paul Fatt (13 January 1924 – 28 September 2014) was a British neuroscientist, who was a professor at University College London. With Bernard Katz, he developed the "quantal hypothesis" for neurotransmitter A neurotransmitter is a sign ...

that neurotransmitter release at synapses is "

quantal In physics, a quantum (: quanta) is the minimum amount of any physical entity (physical property) involved in an interaction. The fundamental notion that a property can be "quantized" is referred to as "the hypothesis of quantization". This me ...

", meaning that at any particular synapse, the amount of neurotransmitter released is never less than a certain amount, and if more is always an integral number times this amount. Scientists now understand that this circumstance arises because, prior to their release into the synaptic gap, transmitter molecules reside in like-sized subcellular packages known as

synaptic vesicle In a neuron, synaptic vesicles (or neurotransmitter vesicles) store various neurotransmitters that are exocytosis, released at the chemical synapse, synapse. The release is regulated by a voltage-dependent calcium channel. Vesicle (biology), Ves ...

s, released in a similar way to any other

vesicle Vesicle may refer to: ; In cellular biology or chemistry * Vesicle (biology and chemistry), a supramolecular assembly of lipid molecules, like a cell membrane * Synaptic vesicle ; In human embryology * Vesicle (embryology), bulge-like features ...

during

exocytosis Exocytosis is a term for the active transport process that transports large molecules from cell to the extracellular area. Hormones, proteins and neurotransmitters are examples of large molecules that can be transported out of the cell. Exocytosis ...

. Katz's work had immediate influence on the study of

organophosphate In organic chemistry, organophosphates (also known as phosphate esters, or OPEs) are a class of organophosphorus compounds with the general structure , a central phosphate molecule with alkyl or aromatic substituents. They can be considered ...

s and

organochlorine Organochlorine chemistry is concerned with the properties of organochlorine compounds, or organochlorides, organic compounds that contain one or more carbon–chlorine bonds. The chloroalkane class (alkanes with one or more hydrogens substituted ...

s, the basis of new post-war study for

nerve agent Nerve agents, sometimes also called nerve gases, are a class of organic chemistry, organic chemicals that disrupt the mechanisms by which nerves transfer messages to organs. The disruption is caused by the blocking of acetylcholinesterase (ACh ...

s and

pesticide Pesticides are substances that are used to control pests. They include herbicides, insecticides, nematicides, fungicides, and many others (see table). The most common of these are herbicides, which account for approximately 50% of all p ...

s, as he determined that the complex enzyme cycle was easily disrupted.

References

External links

Bernard Katz Papers
at

Sir Bernard Katz Biography
Nobel Foundation

* Sabbatini, R.M.E.

''Brain & Mind'', 2004.
Physiology Online, PhysiologyNews, Issue 52, Autumn 2003

König-Albert-Gymnasium Leipzig
* * {{DEFAULTSORT:Katz, Bernard 1911 births 2003 deaths Nobel laureates in Physiology or Medicine British Nobel laureates German Nobel laureates British neuroscientists German neuroscientists Jewish neuroscientists Jewish German scientists Physicians from Leipzig Alumni of University College London Academics of University College London Recipients of the Copley Medal Knights Bachelor Fellows of the Royal Society Foreign associates of the National Academy of Sciences Jewish emigrants from Nazi Germany to the United Kingdom Electrophysiologists Neurophysiologists The Journal of Physiology editors Recipients of the Cothenius Medal

Life and career

Research

See also

References

External links