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BerEp4 (also Ber-EP4) is a histologic stain mainly used to aid in the diagnosis of
BerEp4 (also Ber-EP4) is a histologic stain mainly used to aid in the diagnosis of basal cell carcinoma
Basal-cell carcinoma (BCC), also known as basal-cell cancer, basalioma, or rodent ulcer, is the most common type of skin cancer. It often appears as a painless, raised area of skin, which may be shiny with Telangiectasia, small blood vessels ru ...
(BCC). It is an antibody to EpCAM (epithelial cell adhesion molecule
Epithelial cell adhesion molecule (EpCAM), also known as CD326 among other names, is a transmembrane glycoprotein mediating Ca2+-independent homotypic cell–cell adhesion in epithelia. EpCAM is also involved in cell signaling, migration, pro ...
).
Clinical use
BerEp4 has a highsensitivity and specificity
In medicine and statistics, sensitivity and specificity mathematically describe the accuracy of a test that reports the presence or absence of a medical condition. If individuals who have the condition are considered "positive" and those who do ...
in being positive only in BCC cells. BerEp4 is normally negative in squamous epithelium and mesothelium
The mesothelium is a membrane composed of simple squamous epithelium, simple squamous epithelial cells of mesodermal origin, which forms the lining of several body cavities: the pleura (pleural cavity around the lungs), peritoneum (abdominopelvic ...
, but otherwise normally positive most epithelial cells of the body. It can also help in distinguishing pulmonary adenocarcinoma
Adenocarcinoma (; plural adenocarcinomas or adenocarcinomata ; AC) is a type of cancerous tumor that can occur in several parts of the body. It is defined as neoplasia of epithelial tissue that has glandular origin, glandular characteristics, or ...
(positive BerEp4) from mesothelioma
Mesothelioma is a type of cancer that develops from the thin layer of tissue that covers many of the internal organs (known as the mesothelium). The area most commonly affected is the lining of the lungs and chest wall. Less commonly the lini ...
(generally negative BerEp4).{{cite journal, last1=Ordóñez, first1=Nelson G., title=Value of the Ber-EP4 Antibody in Differentiating Epithelial Pleural Mesothelioma From Adenocarcinoma:The M.D. Anderson Experience and a Critical Review of the Literature, journal=American Journal of Clinical Pathology, volume=109, issue=1, year=1998, pages=85–89, issn=0002-9173, doi=10.1093/ajcp/109.1.85, pmid=9426522, doi-access=free
See also
* List of histologic stains that aid in diagnosis of cutaneous conditionsReferences