Benzoxazines are a group of

isomer In chemistry, isomers are molecules or polyatomic ions with identical molecular formula – that is, the same number of atoms of each element (chemistry), element – but distinct arrangements of atoms in space. ''Isomerism'' refers to the exi ...

ic bicyclic heterocyclic chemical compounds that consist of a

benzene Benzene is an Organic compound, organic chemical compound with the Chemical formula#Molecular formula, molecular formula C6H6. The benzene molecule is composed of six carbon atoms joined in a planar hexagonal Ring (chemistry), ring with one hyd ...

ring fused to an oxazine ring. The different isomers depend on the relative positions of the oxygen and nitrogen atoms in the oxazine ring, on the location of ring fusion, and on the position of the double bond in the oxazine ring. They have the molecular formula C₈H₇NO.

Preparation

1,3-Benzoxazines can be synthesized by the Mannich reaction using a phenol, an amine, and formaldehyde.

Uses

Pharmaceutical drugs

Benzoxazine rings form the central chemical structure of a number of pharmaceutical drugs including, for example, apararenone, elbasvir, and etifoxine.

Polymers

Polybenzoxazines, also called benzoxazine resins, are a class of polymers that are produced from the ring-opening polymerization of 3-phenyl-2,4-dihydro-1,3-benzoxazine monomers and its chemical derivatives. The main applications of polybenzoxazines are as adhesives and in fiber-reinforced plastics.

References

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