Benidipine is a dihydropyridine calcium channel blocker for the treatment of high blood pressure (hypertension). It is a triple L-, T-, and N-type

calcium channel blocker Calcium channel blockers (CCB), calcium channel antagonists or calcium antagonists are a group of medications that disrupt the movement of calcium () through calcium channels. Calcium channel blockers are used as antihypertensive drugs, i.e., as ...

. It is reno- and cardioprotective. It was patented in 1981 and approved for medical use in 1991.

Dosing

Benidipine is dosed as 2–8 mg once daily.

Mechanism

Benidipine is a

. Benidipine has additionally been found to act as an

antagonist An antagonist is a character in a story who is presented as the main enemy or rival of the protagonist and is often depicted as a villain.mineralocorticoid receptor The mineralocorticoid receptor (or MR, MLR, MCR), also known as the aldosterone receptor or nuclear receptor subfamily 3, group C, member 2, (NR3C2) is a protein that in humans is encoded by the ''NR3C2'' gene that is located on chromosome 4q31 ...

, or as an

antimineralocorticoid A mineralocorticoid receptor antagonist (MRA or MCRA) or aldosterone antagonist, is a diuretic drug which receptor antagonist, antagonizes the action of aldosterone at mineralocorticoid receptors. This group of drugs is often used as adjunctive t ...

Names

Other names include Benidipinum or benidipine hydrochloride. Benidipine is sold as Coniel by Kyowa Hakko Kogyo. Benidipine is initially licensed for use in Japan and selected

Southeast Asian Southeast Asia is the geographical southeastern region of Asia, consisting of the regions that are situated south of China, east of the Indian subcontinent, and northwest of the Australian mainland, which is part of Oceania. Southeast Asia is ...

countries and later in Turkey, where it is sold as 4 mg tablets.

References

{{Mineralocorticoidics Antimineralocorticoids Calcium channel blockers Carboxylate esters Dihydropyridines Methyl esters 3-Nitrophenyl compounds Piperidines