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Bcl-2-interacting killer is a protein that in humans is encoded by the ''BIK'' gene.


Function

The protein encoded by this gene is known to interact with cellular and viral survival-promoting proteins, such as BCL2 and the Epstein–Barr virus in order to enhance programmed cell death. Because its activity is suppressed in the presence of survival-promoting proteins, this protein is suggested as a likely target for antiapoptotic proteins. This protein shares a critical BH3 domain with other death-promoting proteins, BAX and BAK.


Interactions

Bcl-2-interacting killer has been shown to interact with BCL2-like 1 and Bcl-2.


References


External links

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Further reading

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