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The bZIP intron animal is an unconventional bZIP intron in animals located in the mRNA of
Xbp1 X-box binding protein 1, also known as XBP1, is a protein which in humans is encoded by the ''XBP1'' gene. The ''XBP1'' gene is located on chromosome 22 while a closely related pseudogene has been identified and localized to chromosome 5. The XBP ...
orthologs. The RNA structure consists of two hairpins of similar length with loop regions defining the splice sites.
Intron An intron is any nucleotide sequence within a gene that is not expressed or operative in the final RNA product. The word ''intron'' is derived from the term ''intragenic region'', i.e. a region inside a gene."The notion of the cistron .e., gene. ...
is usually 23 or 26 nt long and it is excised by endoribonuclease
Ire1 The serine/threonine-protein kinase/endoribonuclease inositol-requiring enzyme 1 α (IRE1α) is an enzyme that in humans is encoded by the ''ERN1'' gene. Function The protein encoded by this gene is the ER to nucleus signalling 1 protein, a hu ...
encoded by
ERN1 The serine/threonine-protein kinase/endoribonuclease inositol-requiring enzyme 1 α (IRE1α) is an enzyme that in humans is encoded by the ''ERN1'' gene. Function The protein encoded by this gene is the ER to nucleus signalling 1 protein, a hu ...
gene in response to ER stress. The splicing mechanism in this group was first reported in human.


References

{{reflist RNA splicing Non-coding RNA