BT-20 is a
breast cancer
Breast cancer is cancer that develops from breast tissue. Signs of breast cancer may include a lump in the breast, a change in breast shape, dimpling of the skin, milk rejection, fluid coming from the nipple, a newly inverted nipple, or ...
cell line
An immortalised cell line is a population of cells from a multicellular organism which would normally not proliferate indefinitely but, due to mutation, have evaded normal cellular senescence and instead can keep undergoing division. The cel ...
derived from a 74-year-old human female in 1958 by E.Y. Lasfargues and L. Ozzello. The cells technically came from a
triple-negative breast cancer, which was caused by an invasive ductal carcinoma in the
mammary gland
A mammary gland is an exocrine gland in humans and other mammals that produces milk to feed young offspring. Mammals get their name from the Latin word ''mamma'', "breast". The mammary glands are arranged in organs such as the breasts in pr ...
. BT-20 cells are known to have amplified regions of chromosomes 6, 11, and 20, with most cells being hyperdiploid.
The cells express an
estrogen receptor
Estrogen receptors (ERs) are a group of proteins found inside cells. They are receptors that are activated by the hormone estrogen (17β-estradiol). Two classes of ER exist: nuclear estrogen receptors ( ERα and ERβ), which are members of th ...
with a deletion of
exon
An exon is any part of a gene that will form a part of the final mature RNA produced by that gene after introns have been removed by RNA splicing. The term ''exon'' refers to both the DNA sequence within a gene and to the corresponding sequenc ...
5, and are used in
preclinical studies of breast cancer.
References
External links
Cellosaurus entry for BT-20
Human cell lines
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