BP-897 is a drug used in scientific research which acts as a potent selective
dopamine
Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is a neuromodulatory molecule that plays several important roles in cells. It is an organic chemical of the catecholamine and phenethylamine families. It is an amine synthesized ...
D3 receptor, D
3 Receptor (biochemistry), receptor partial agonist with an in vitro intrinsic activity of ~0.6 and ~70x greater affinity for D
3 over D
2 receptors and is suspected to have partial agonist or antagonist activity in vivo.
It has mainly been used in the study of treatments for cocaine addiction.
A study comparing BP-897 with the potent, antagonistic, and highly D
3 selective SB-277,011-A found, "SB 277011-A (1–10 mg/kg) was able to block cue-induced reinstatement of nicotine-seeking, indicating that DRD3 selective antagonism may be an effective approach to prevent relapse for nicotine. In contrast, BP 897 did not block the cue-induced reinstatement of nicotine-seeking or nicotine-taking under the FR5 schedule."
References
Dopamine agonists
2-Naphthyl compounds
Carboxamides
Phenylpiperazines
2-Methoxyphenyl compounds
Experimental psychiatric drugs
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