Ribosome biogenesis protein BOP1 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''BOP1''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
It is a
WD40 repeat-containing
nucleolar protein involved in rRNA processing, thereby controlling the
cell cycle.
It is required for the maturation of the 25S and 5.8S
ribosomal RNAs. It may serve as an essential factor in
ribosome formation that coordinates processing of the spacer regions in pre-rRNA.
Function
The Pes1-Bop1
complex has several components: BOP1,
GRWD1,
PES1,
ORC6L, and
RPL3 and is involved in ribosome
biogenesis and altered
chromosome segregation. The overexpression of BOP1 increases the percentage of
multipolar spindles in
human cells. Deregulation of the BOP1 pathway may contribute to colorectal tumourigenesis in
human
Humans (''Homo sapiens'') or modern humans are the most common and widespread species of primate, and the last surviving species of the genus ''Homo''. They are Hominidae, great apes characterized by their Prehistory of nakedness and clothing ...
s.
Elevated levels of Bop1 induces Bop1/WDR12 and Bop1/Pes1 subcomplexes and the assembly and integrity of the PeBoW complex is highly sensitive to changes in Bop1 protein levels.
Nop7p-
Erb1p-Ytm1p, found in yeast, is potentially the
homologous complex of Pes1-Bop1-WDR12 as it is involved in the control of ribosome biogenesis and
S phase entry. The integrity of the PeBoW complex is required for ribosome biogenesis and cell proliferation in
mammalian
cells.
In Giardia, the
species
A species () is often defined as the largest group of organisms in which any two individuals of the appropriate sexes or mating types can produce fertile offspring, typically by sexual reproduction. It is the basic unit of Taxonomy (biology), ...
specific
cytoskeleton protein, beta-giardin,
interacts with Bop1.
Structure
BOP1 contains a conserved
N-terminal domain, BOP1NT.
References
External links
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Protein domains
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