BMP binding endothelial regulator is a

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respon ...

that in humans is encoded by the ''BMPER''

gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...

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KLF15 Krüppel-like factor 15 is a protein that in humans is encoded by the ''KLF15'' gene in the Krüppel-like factor family. Its former designation KKLF stands for kidney-enriched Krüppel-like factor. Expression Activated glucocorticoid recepto ...

is a strong and direct activator of BMPER expression which is inhibited by SP1. BMPER is inhibited by

endothelin-1 Endothelin 1 (ET-1), also known as preproendothelin-1 (PPET1), is a potent vasoconstrictor peptide produced by vascular endothelial cells. The protein encoded by this gene ''EDN1'' is proteolytically processed to release endothelin 1. Endotheli ...

, which may be mediated by endothelin inhibition of KLF15.

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