BML-190 (Indomethacin morpholinylamide) is a drug used in scientific research that acts as a selective CB₂

inverse agonist In pharmacology, an inverse agonist is a drug that binds to the same receptor as an agonist but induces a pharmacological response opposite to that of the agonist. A neutral antagonist has no activity in the absence of an agonist or inverse agon ...

. BML-190 is structurally derived from the

NSAID Non-steroidal anti-inflammatory drugs (NSAID) are members of a therapeutic drug class which reduces pain, decreases inflammation, decreases fever, and prevents blood clots. Side effects depend on the specific drug, its dose and duration of ...

indomethacin Indometacin, also known as indomethacin, is a nonsteroidal anti-inflammatory drug (NSAID) commonly used as a prescription medication to reduce fever, pain, stiffness, and swelling from inflammation. It works by inhibiting the production of pr ...

but has a quite different biological activity. The activity produced by this compound is disputed, with some sources referring to it as a CB₂

agonist An agonist is a chemical that activates a Receptor (biochemistry), receptor to produce a biological response. Receptors are Cell (biology), cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an R ...

rather than an inverse agonist; this may reflect an error in classification, or alternatively it may produce different effects in different tissues, and more research is required to resolve this dispute.

References

2-Alkyltryptamines Benzamides Cannabinoids 4-Chlorophenyl compounds N,N-Dialkyltryptamines Indole ethers at the benzene ring 5-Methoxytryptamines 4-Morpholinyl compounds {{cannabinoid-stub