Bcl-2-like protein 1 is a protein encoded in humans by the ''BCL2L1''
gene. Through
alternative splicing
Alternative splicing, or alternative RNA splicing, or differential splicing, is an alternative splicing process during gene expression that allows a single gene to code for multiple proteins. In this process, particular exons of a gene may be ...
, the gene encodes both of the human proteins
Bcl-xL and
Bcl-xS.
Function
The protein encoded by this gene belongs to the
Bcl-2 protein family. Bcl-2 family members form hetero- or homodimers and act as anti- or pro-
apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the
outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (
voltage-dependent anion channels (VDACs) opening. VDACs regulate mitochondrial membrane potential, and thus controls the production of
reactive oxygen species and release of
cytochrome C
The cytochrome complex, or cyt ''c'', is a small hemeprotein found loosely associated with the inner membrane of the mitochondrion. It belongs to the cytochrome c family of proteins and plays a major role in cell apoptosis. Cytochrome c is hig ...
by mitochondria, both of which are the potent inducers of
cell apoptosis
Apoptosis (from grc, wikt:ἀπόπτωσις, ἀπόπτωσις, apóptōsis, 'falling off') is a form of programmed cell death that occurs in multicellular organisms. Biochemistry, Biochemical events lead to characteristic cell changes (Morp ...
. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform (
Bcl-xL) acts as an apoptotic inhibitor and the shorter form (Bcl-xS) acts as an apoptotic activator.
Interactions
BCL2-like 1 (gene) has been shown to
interact with:
*
APAF1,
*
BAK1
Bcl-2 homologous antagonist/killer is a protein that in humans is encoded by the ''BAK1'' gene on chromosome 6. The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as ant ...
,
BAD
Bad or BAD may refer to:
Common meanings
*Evil, the opposite of moral good
* Erroneous, inaccurate or incorrect
* Unhealthy, or counter to well-being
* Antagonist, the threat or obstacle of moral good
Acronyms
* BAD-2, a Soviet armored troll ...
,PSEN2
Presenilin-2 is a protein that (in humans) is encoded by the ''PSEN2'' gene.
Function
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins ( PSEN1; PSEN2) or the amyloid precursor ...
RTN4
Reticulon 4, also known as Neurite outgrowth inhibitor or Nogo, is a protein that in humans is encoded by the ''RTN4'' gene that has been identified as an Enzyme inhibitor, inhibitor of neurite outgrowth specific to the central nervous system. Du ...
,[ and
* VDAC1.]
References
Further reading
*
External links
*
{{PDB Gallery, geneid=598
Proteins
Apoptosis