Bcl-2-like protein 1 is a protein encoded in humans by the ''BCL2L1''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
. Through
alternative splicing
Alternative splicing, alternative RNA splicing, or differential splicing, is an alternative RNA splicing, splicing process during gene expression that allows a single gene to produce different splice variants. For example, some exons of a gene ma ...
, the gene encodes both of the human proteins
Bcl-xL and
Bcl-xS.
Function
The protein encoded by this gene belongs to the
Bcl-2 protein family. Bcl-2 family members form hetero- or homodimers and act as anti- or pro-
apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the
outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (
voltage-dependent anion channels (VDACs) opening. VDACs regulate mitochondrial membrane potential, and thus controls the production of
reactive oxygen species
In chemistry and biology, reactive oxygen species (ROS) are highly Reactivity (chemistry), reactive chemicals formed from diatomic oxygen (), water, and hydrogen peroxide. Some prominent ROS are hydroperoxide (H2O2), superoxide (O2−), hydroxyl ...
and release of
cytochrome C by mitochondria, both of which are the potent inducers of
cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform (
Bcl-xL) acts as an apoptotic inhibitor and the shorter form (Bcl-xS) acts as an apoptotic activator.
Interactions
BCL2-like 1 (gene) has been shown to
interact with:
*
APAF1,
*
BAK1,
Bcl-2
Bcl-2, encoded in humans by the ''BCL2'' gene, is the founding member of the Bcl-2 family of regulator proteins. BCL2 blocks programmed cell death (apoptosis) while other BCL2 family members can either inhibit or induce it. It was the first a ...
,PPP1CA
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit is an enzyme that in humans is encoded by the ''PPP1CA'' gene.
Function
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). P ...
,RTN1
Reticulon-1 also known as neuroendocrine-specific protein (NSP) is a protein that in humans is encoded by the ''RTN1'' gene.
This gene belongs to the family of reticulon-encoding genes. Reticulons are associated with the endoplasmic reticulum, an ...
,RTN4
Reticulon 4, also known as Neurite outgrowth inhibitor or Nogo, is a protein that in humans is encoded by the ''RTN4'' gene that has been identified as an inhibitor of neurite outgrowth specific to the central nervous system. During neural deve ...
,[ and
* VDAC1.]
References
Further reading
*
External links
*
{{PDB Gallery, geneid=598
Proteins
Apoptosis