BB-Cl-Amidine is an experimental drug which acts as a non-subtype selective, irreversible inhibitor of the enzyme peptidylarginine deiminase (PAD). It has anti-cancer effects and is useful for various inflammatory conditions such as

arthritis Arthritis is a general medical term used to describe a disorder that affects joints. Symptoms generally include joint pain and stiffness. Other symptoms may include redness, warmth, Joint effusion, swelling, and decreased range of motion of ...

, and while it may be unlikely to be developed for human use due to toxicity concerns, it is widely used in scientific research. As well as its activity as a PAD inhibitor, BB-Cl-Amidine also inhibits the action of the

Stimulator of interferon genes Stimulator of interferon genes (STING), also known as transmembrane protein 173 (TMEM173) and MPYS/MITA/ERIS is a regulator protein that in humans is encoded by the STING1 gene. STING plays an important role in innate immunity. STING induces typ ...

(STING) protein by preventing STING oligomerization and thereby terminating the signalling pathway.

References

{{reflist Experimental drugs Biphenyls Benzamides Benzimidazoles Amidines Organochlorides

See also

References