Large proline-rich protein BAT2 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respon ...
that in humans is encoded by the ''BAT2''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
Function
A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for
TNF alpha and
TNF beta. These genes are all within the human
major histocompatibility complex class III region. This gene has microsatellite repeats which are associated with the age-at-onset of
insulin-dependent diabetes mellitus (IDDM) and possibly thought to be involved with the inflammatory process of pancreatic beta-cell destruction during the development of IDDM. This gene is also a candidate gene for the development of rheumatoid arthritis. There are two alternatively spliced transcripts encoding different isoforms described for this gene.
Interactions
BAT2 has been shown to
interact with:
*
C1QBP,
[
* EIF3S6,][
* ]HNRNPA1
Heterogeneous nuclear ribonucleoprotein A1 is a protein that in humans is encoded by the ''HNRNPA1'' gene. Mutations in hnRNP A1 are causative of amyotrophic lateral sclerosis and the syndrome multisystem proteinopathy.
Function
This gene ...
,[
* ]IFT88
Intraflagellar transport protein 88 homolog is a protein that is encoded by the ''IFT88'' gene.
Function
This gene encodes a member of the tetratrico peptide repeat (TPR) family. Mutations of a similar gene in mouse can cause polycystic kidney ...
,IMMT
Mitochondrial inner membrane protein is a protein that in humans is encoded by the ''IMMT'' gene.)
''IMMT'' encodes an inner mitochondrial membrane (IMM) protein in the nucleus. It is posttranslational transported to the IMM. Mic60/Mitofilin (e ...
,[ and
* ]UBAP2L
Ubiquitin-associated protein 2-like is a protein that in humans is encoded by the ''UBAP2L'' gene.
Interactions
UBAP2L has been shown to interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 5 ...
.[
]
References
Further reading
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External links
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