Azumolene is an experimental drug which is a derivative of

dantrolene Dantrolene sodium, sold under the brand name Dantrium among others, is a postsynaptic muscle relaxant that lessens excitation-contraction coupling in muscle cells. It achieves this by inhibiting Ca2+ ions release from sarcoplasmic reticul ...

. In animal studies, azumolene showed similar efficacy to dantrolene at controlling symptoms of

malignant hyperthermia Malignant hyperthermia (MH) is a type of severe reaction that occurs in response to particular medications used during general anesthesia, among those who are susceptible. Symptoms include muscle rigidity, fever, and a fast heart rate. Complica ...

but with better water solubility and lower toxicity, albeit with lower potency.

References

Furans Hydantoins Muscle relaxants 4-Bromophenyl compounds {{musculoskeletal-drug-stub