Avadomide (CC-122) is an experimental

cereblon E3 ligase modulator Cereblon E3 ligase modulators, also known as immunomodulatory imide drugs (IMiDs), are a class of immunomodulatory drugs (drugs that adjust immune responses) containing an imide group. The IMiD class includes thalidomide and its analogues (len ...

, or

thalidomide Thalidomide, sold under the brand names Contergan and Thalomid among others, is an oral administered medication used to treat a number of cancers (e.g., multiple myeloma), graft-versus-host disease, and many skin disorders (e.g., complication ...

analog (

molecular glue A molecular glue is a type of small molecule that modulates protein–protein interactions in cells by enhancing the affinity between proteins. These compounds can induce novel interactions between proteins (type I) or stabilize pre-existing one ...

) that was discovered and studied by Celgene to see if it was effective against cancer. The deuterated S-enantiomer, SP-3164 (DRX-164) is in development at Salarius Pharmaceuticals.

References

{{reflist Cereblon E3 ligase modulators Drugs developed by Bristol Myers Squibb Glutarimides Quinazolinones Anilines