Aspidophytine is an
indole
Indole is an aromatic heterocyclic organic compound with the formula C8 H7 N. It has a bicyclic structure, consisting of a six-membered benzene ring fused to a five-membered pyrrole ring. Indole is widely distributed in the natural environme ...
alkaloid
Alkaloids are a class of basic
BASIC (Beginners' All-purpose Symbolic Instruction Code) is a family of general-purpose, high-level programming languages designed for ease of use. The original version was created by John G. Kemeny and Th ...
that has attracted a lot of attention from synthetic chemists.
[''"A Concise Asymmetric Total Synthesis of Aspidophytine" ''Nicolaou, K. C., Dalby, S. M., Majumder, U. ''J. Am. Chem. Soc.'' 2008, ''130(45)'', 14942–14943 ()] An extract of the
cockroach plant, aspidophytine is an
insecticidal
Insecticides are substances used to kill insects. They include ovicides and larvicides used against insect eggs and larvae, respectively. Insecticides are used in agriculture, medicine, industry and by consumers. Insecticides are claimed t ...
substance particularly effective against
cockroach
Cockroaches (or roaches) are a Paraphyly, paraphyletic group of insects belonging to Blattodea, containing all members of the group except termites. About 30 cockroach species out of 4,600 are associated with human habitats. Some species are we ...
es. It is one of the two components of the
dimer
Dimer may refer to:
* Dimer (chemistry), a chemical structure formed from two similar sub-units
** Protein dimer, a protein quaternary structure
** d-dimer
* Dimer model, an item in statistical mechanics, based on ''domino tiling''
* Julius Dimer ( ...
haplophytine.
[Column: Totally Synthetic]
by Paul Docherty, at the Royal Society of Chemistry
The Royal Society of Chemistry (RSC) is a learned society (professional association) in the United Kingdom with the goal of "advancing the chemistry, chemical sciences". It was formed in 1980 from the amalgamation of the Chemical Society, the Ro ...
; published October 9, 2009; retrieved October 3, 2014
In his suicide note, Harvard doctoral student
Jason Altom mentioned his stress in attempting to devise a synthetic pathway for the aspidophytine sub-unit of haplophytine as a contributing factor to his psychological breakdown.
[Lethal Chemistry at Harvard]
by Stephen S> Hall, in ''the New York Times
''The New York Times'' (''the Times'', ''NYT'', or the Gray Lady) is a daily newspaper based in New York City with a worldwide readership reported in 2020 to comprise a declining 840,000 paid print subscribers, and a growing 6 million paid ...
''; published November 29, 1998; retrieved October 3, 2014
References
Tryptamine alkaloids
Alkaloids found in Apocynaceae
Lactones
Catechol ethers
Indolizidines
Phenethylamine alkaloids
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