The vasa recta of the kidney, (vasa recta renis) are the straight arterioles, and the straight venules of the

kidney In humans, the kidneys are two reddish-brown bean-shaped blood-filtering organ (anatomy), organs that are a multilobar, multipapillary form of mammalian kidneys, usually without signs of external lobulation. They are located on the left and rig ...

, – a series of

blood vessel Blood vessels are the tubular structures of a circulatory system that transport blood throughout many Animal, animals’ bodies. Blood vessels transport blood cells, nutrients, and oxygen to most of the Tissue (biology), tissues of a Body (bi ...

s in the blood supply of the kidney that enter the medulla as the straight arterioles, and leave the medulla to ascend to the cortex as the straight venules. (

Latin Latin ( or ) is a classical language belonging to the Italic languages, Italic branch of the Indo-European languages. Latin was originally spoken by the Latins (Italic tribe), Latins in Latium (now known as Lazio), the lower Tiber area aroun ...

: ''vās'', "vessel"; ''rēctus'', "straight"). They lie parallel to the

loop of Henle In the kidney, the loop of Henle () (or Henle's loop, Henle loop, nephron loop or its Latin counterpart ''ansa nephroni'') is the portion of a nephron that leads from the proximal convoluted tubule to the distal convoluted tubule. Named after it ...

. These vessels branch off the

efferent arterioles The efferent arterioles are blood vessels that are part of the urinary tract of organisms. Efferent (from Latin ex + ferre) means "outgoing", in this case meaning carrying blood out away from the glomerulus. The efferent arterioles form a converg ...

of juxtamedullary nephrons (those

nephron The nephron is the minute or microscopic structural and functional unit of the kidney. It is composed of a renal corpuscle and a renal tubule. The renal corpuscle consists of a tuft of capillaries called a glomerulus and a cup-shaped structu ...

s closest to the medulla). They enter the medulla, and surround the loop of Henle. Whereas the

peritubular capillaries In the renal system, peritubular capillaries are tiny blood vessels, supplied by the efferent arteriole, that travel alongside nephrons allowing reabsorption and secretion between blood and the inner lumen of the nephron. Peritubular capillaries ...

surround the cortical parts of the tubules, the vasa recta go into the medulla and are closer to the loop of Henle, and leave to ascend to the cortex. Terminations of the vasa recta form the straight venules, branches from the plexuses at the apices of the

medullary pyramids In neuroanatomy, the medullary pyramids are paired white matter structures of the brainstem's medulla oblongata that contain motor fibers of the corticospinal and corticobulbar tracts – known together as the pyramidal tracts. The lower limit ...

. They run outward in a straight course between the tubes of the medullary substance and join the

interlobular veins The stellate veins join to form the interlobular veins, which pass inward between the Medullary ray (anatomy), rays, receive branches from the plexuses around the convoluted tubules, and, having arrived at the bases of the renal pyramids, join with ...

to form venous arcades. These in turn unite and form veins which pass along the sides of the renal pyramids. The descending vasa recta have a non-fenestrated endothelium that contains a facilitated transport for urea; the ascending vasa recta have, on the other hand, a fenestrated endothelium.

Structure

Microanatomy

On a histological slide, the straight arterioles can be distinguished from the tubules of the

by the presence of blood.

Function

Each straight arteriole has a hairpin turn in the medulla and carries blood at a very slow rate – two factors crucial in the maintenance of

countercurrent exchange Countercurrent exchange is a mechanism between two flowing bodies flowing in opposite directions to each other, in which there is a transfer of some property, usually heat or some chemical. The flowing bodies can be liquids, gases, or even solid ...

that prevent washout of the concentration gradients established in the renal medulla. The maintenance of this concentration gradient is one of the components responsible for the kidney's ability to produce concentrated

urine Urine is a liquid by-product of metabolism in humans and many other animals. In placental mammals, urine flows from the Kidney (vertebrates), kidneys through the ureters to the urinary bladder and exits the urethra through the penile meatus (mal ...

. On the descending portion of the vasa recta, sodium, chloride and urea are reabsorbed into the blood, while water is secreted. On the ascending portion, sodium chloride and urea are secreted into the interstitium, while water is reabsorbed.

Clinical significance

The slow blood flow in the straight arterioles makes them a likely location of

thrombosis Thrombosis () is the formation of a Thrombus, blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system. When a blood vessel (a vein or an artery) is injured, the body uses platelets (thrombocytes) and fib ...

from

thrombophilia Thrombophilia (sometimes called hypercoagulability or a prothrombotic state) is an abnormality of blood coagulation that increases the risk of thrombosis (blood clots in blood vessels). Such abnormalities can be identified in 50% of people who ...

, or tissue loss due to red blood cell sickling in

sickle cell disease Sickle cell disease (SCD), also simply called sickle cell, is a group of inherited Hemoglobinopathy, haemoglobin-related blood disorders. The most common type is known as sickle cell anemia. Sickle cell anemia results in an abnormality in the ...

Ischemia Ischemia or ischaemia is a restriction in blood supply to any tissue, muscle group, or organ of the body, causing a shortage of oxygen that is needed for cellular metabolism (to keep tissue alive). Ischemia is generally caused by problems ...

that results may lead to

renal papillary necrosis Renal papillary necrosis is a form of nephropathy involving the necrosis of the renal papilla. Lesions that characterize renal papillary necrosis come from an impairment of the blood supply and from subsequent ischemic necrosis that is diffuse. Sig ...

Nomenclature

According to

Terminologia Anatomica ''Terminologia Anatomica'' (commonly abbreviated TA) is the international standard for human anatomy, human anatomical terminology. It is developed by the Federative International Programme on Anatomical Terminology (FIPAT) a program of the Inter ...

, the term "vasa recta renis" is an alternate name for "arteriolae rectae renis", and a separate term, venulae rectae renis, is used to identify the venous portion. However, other sources consider "vasa recta" to refer to both the arterial and venous portions. The term ''vasa recta'' is also used for the intestines –

vasa recta (intestines) Vasa recta are straight arteries arising from arterial arcades (anastomoses of the jejunal and ileal arteries, branches of superior mesenteric artery) in the mesentery of the jejunum and ileum that supply the jejunum and ileum. The vasa recta o ...

(in the

ileum The ileum () is the final section of the small intestine in most higher vertebrates, including mammals, reptiles, and birds. In fish, the divisions of the small intestine are not as clear and the terms posterior intestine or distal intestine may ...

and

jejunum The jejunum is the second part of the small intestine in humans and most higher vertebrates, including mammals, reptiles, and birds. Its lining is specialized for the absorption by enterocytes of small nutrient molecules which have been pr ...

)

References

External links

* {{Authority control Kidney anatomy