Arotinolol (

INN Inns are generally establishments or buildings where travelers can seek lodging, and usually, food and drink. Inns are typically located in the country or along a highway. Before the advent of motorized transportation, they also provided accomm ...

, marketed under the tradename Almarl) is a

medication Medication (also called medicament, medicine, pharmaceutical drug, medicinal product, medicinal drug or simply drug) is a drug used to medical diagnosis, diagnose, cure, treat, or preventive medicine, prevent disease. Drug therapy (pharmaco ...

in the class of mixed

alpha Alpha (uppercase , lowercase ) is the first letter of the Greek alphabet. In the system of Greek numerals, it has a value of one. Alpha is derived from the Phoenician letter ''aleph'' , whose name comes from the West Semitic word for ' ...

beta blocker Beta blockers, also spelled β-blockers, are a class of medications that are predominantly used to manage abnormal heart rhythms ( arrhythmia), and to protect the heart from a second heart attack after a first heart attack ( secondary prevention ...

s. It also acts as a β₃ receptor

agonist An agonist is a chemical that activates a Receptor (biochemistry), receptor to produce a biological response. Receptors are Cell (biology), cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an R ...

. A 1979 publication suggests arotinolol as having first been described in the scientific literature by

Sumitomo Chemical is a major Japanese chemical company. The company is listed on the first section of the Tokyo Stock Exchange and is a constituent of the on the Nikkei 225 stock index. It's a member of the Sumitomo group and was founded in 1913 as a fertilize ...

as "β-adrenergic blocking, antiarrhythmic compound S-596".

Medical uses

It is used in the treatment of

high blood pressure Hypertension, also known as high blood pressure, is a long-term medical condition in which the blood pressure in the arteries is persistently elevated. High blood pressure usually does not cause symptoms itself. It is, however, a major ri ...

and

essential tremor Essential tremor (ET), also called benign tremor, familial tremor, and idiopathic tremor, is a medical condition characterized by involuntary rhythmic contractions and relaxations ( oscillations or twitching movements) of certain muscle groups i ...

. Recommended dosage is 10 to 30 mg per day.

References

External links

*
Almarl Full Prescribing Information. Revised November 2009
Sumitomo Dainippon Pharma Co., Ltd. *
Official Sumitomo Dainippon Pharma Website
* {{Adrenergic receptor modulators Alpha-1 blockers Secondary amines Beta blockers Beta3-adrenergic agonists Carboxamides Secondary alcohols Tert-butyl compounds Thiazoles Thioethers Thiophenes