Ariel Darvasi (; February 17, 1962 – September 28, 2018) was a Professor of Genetics and former Head of Life Sciences Studies and Vice Dean of the Faculty of Sciences at
The Hebrew University of Jerusalem
The Hebrew University of Jerusalem (HUJI; ) is an Israeli public research university based in Jerusalem. Co-founded by Albert Einstein and Chaim Weizmann in July 1918, the public university officially opened on 1 April 1925. It is the second-ol ...
.
Biography
Ariel Darvasi was born in
Santiago de Chile
Santiago (, ; ), also known as Santiago de Chile (), is the capital city, capital and largest city of Chile and one of the largest cities in the Americas. It is located in the country's Chilean Central Valley, central valley and is the center ...
. At the age of 10 his family moved to
Israel
Israel, officially the State of Israel, is a country in West Asia. It Borders of Israel, shares borders with Lebanon to the north, Syria to the north-east, Jordan to the east, Egypt to the south-west, and the Mediterranean Sea to the west. Isr ...
and settled in
Jerusalem
Jerusalem is a city in the Southern Levant, on a plateau in the Judaean Mountains between the Mediterranean Sea, Mediterranean and the Dead Sea. It is one of the List of oldest continuously inhabited cities, oldest cities in the world, and ...
.
Darvasi obtained his
BSc degree (with honors) in
Biology
Biology is the scientific study of life and living organisms. It is a broad natural science that encompasses a wide range of fields and unifying principles that explain the structure, function, growth, History of life, origin, evolution, and ...
and
Computer Science
Computer science is the study of computation, information, and automation. Computer science spans Theoretical computer science, theoretical disciplines (such as algorithms, theory of computation, and information theory) to Applied science, ...
in 1988, and his
MSc degree (with honors) and his
PhD
A Doctor of Philosophy (PhD, DPhil; or ) is a terminal degree that usually denotes the highest level of academic achievement in a given discipline and is awarded following a course of graduate study and original research. The name of the deg ...
degree (summa cum laude) in
Genetics
Genetics is the study of genes, genetic variation, and heredity in organisms.Hartl D, Jones E (2005) It is an important branch in biology because heredity is vital to organisms' evolution. Gregor Mendel, a Moravian Augustinians, Augustinian ...
from The Hebrew University of Jerusalem, under the supervision of Moshe Soller. Subsequently, he conducted post-doctoral research at
The University of Paris.
As a young scientist he won the Landau Prize. in 1999, one of Israel's highest honors for sciences.
Between 2006 and 2009 Darvasi was Head of Genetics Studies at the Hebrew University of Jerusalem, and then Head of the entire Life Sciences curriculum until 2012. From 2012 to 2016 Darvasi served as Vice Dean of the Faculty of Sciences of The Hebrew University.
Academic career
Darvasi published over 100 scientific articles. His research can be divided into 5 major themes:
* The theoretical basis of
gene mapping
Gene mapping or genome mapping describes the methods used to identify the location of a gene on a chromosome and the distances between genes. Gene mapping can also describe the distances between different sites within a gene.
The essence of all ...
. The early studies of Darvasi were aimed to develop experimental and computational strategies for the identification of genes affecting
complex traits
Complex traits are phenotypes that are controlled by two or more genes and do not follow Mendel's Law of Dominance. They may have a range of expression which is typically continuous. Both environmental and genetic factors often impact the variat ...
. Several of the strategies developed by Darvasi are widely used by many geneticists all over the world till this day.
* The genetic basis of
chronic pain
Chronic pain is pain that persists or recurs for longer than 3 months.https://icd.who.int/browse/2025-01/mms/en#1581976053 It is also known as gradual burning pain, electrical pain, throbbing pain, and nauseating pain. This type of pain is in cont ...
. Darvasi, in collaboration with Marshall Devor, studied the genetic basis of chronic pain. Using a mouse model they identified a novel gene affecting predisposition to chronic pain. Their findings were shown to affect chronic pain in humans as well.
* The Genetic basis of
schizophrenia
Schizophrenia () is a mental disorder characterized variously by hallucinations (typically, Auditory hallucination#Schizophrenia, hearing voices), delusions, thought disorder, disorganized thinking and behavior, and Reduced affect display, f ...
. Adopting experimental strategies he developed, Darvasi discovered one of the strongest genetic associations at the time (published in the
American Journal of Human Genetics
The ''American Journal of Human Genetics'' is a monthly peer-reviewed scientific journal in the field of human genetics. It was established in 1948 by the American Society of Human Genetics and covers all aspects of heredity in humans, including ...
, 2002) between a gene and predisposition to schizophrenia. More recently, he was part of a large international consortium that discovered over 100 genes affecting schizophrenia (published in
Nature
Nature is an inherent character or constitution, particularly of the Ecosphere (planetary), ecosphere or the universe as a whole. In this general sense nature refers to the Scientific law, laws, elements and phenomenon, phenomena of the physic ...
2014).
* DNA
Forensics
Forensic science combines principles of law and science to investigate criminal activity. Through crime scene investigations and laboratory analysis, forensic scientists are able to link suspects to evidence. An example is determining the time and ...
. Darvasi developed experimental and computational strategies in DNA forensics. He holds a US patent for the identification of a suspect's DNA in a scene of crime where a mixture of DNA from several individuals is present.
* The evolutionary basis of
human behavior
Human behavior is the potential and expressed capacity (Energy (psychological), mentally, Physical activity, physically, and Social action, socially) of human individuals or groups to respond to internal and external Stimulation, stimuli throu ...
. Darvasi's current field of research is the evolutionary basis of human behavior – he teaches a unique course in this topic at The Hebrew University. His interest is in mind mechanisms that drive evolutionary beneficial behaviors. In this context he developed the "Boss Theory", an evolutionary driven theory that aims to describe a conceptual framework for
conscious
Consciousness, at its simplest, is awareness of a state or object, either internal to oneself or in one's external environment. However, its nature has led to millennia of analyses, explanations, and debate among philosophers, scientists, a ...
and
unconscious mind
In psychoanalysis and other psychological theories, the unconscious mind (or the unconscious) is the part of the psyche that is not available to introspection. Although these processes exist beneath the surface of conscious awareness, they are t ...
processes.
Business career
Along with teaching and research, Darvasi founded IDgene, a biotechnology company that studied the genetic basis of common diseases (such as diabetes, asthma, cancer, schizophrenia and many others) as a mean to discover novel therapies. In 1999 the company raised over US$15 million from various venture capital firms, including world leaders such as
Apax Partners
Apax Partners LLP is a British private equity firm, headquartered in London, England. The company also operates out of six other offices in New York, Hong Kong, Mumbai, Tel Aviv, Munich and Shanghai. As of March 2024, the firm had raised and adv ...
. At its peak, IDgene employed 50 employees in its Jerusalem central facilities.
In 2004 the company ceased formal operations and all intellectual property was transferred to the Hebrew University of Jerusalem. Over the years, Darvasi also co-founded several other biotechnology companies in Israel and the US.
In March 2017, Darvasi was under investigation by the
SEC (Security Exchange Commission) for suspicion of alleged insider trading of
Mobileye
Mobileye Global Inc. is a United States- domiciled, Israel-headquartered autonomous driving company. It is developing self-driving technologies and advanced driver-assistance systems (ADAS) including cameras, computer chips, and software. Mobil ...
shares. The case was settled with a fine and no conviction of any wrongdoing
References
{{DEFAULTSORT:Darvasi, Ariel
1962 births
Living people
Scientists from Santiago, Chile
Chilean emigrants to Israel
Hebrew University of Jerusalem alumni
Academic staff of the Hebrew University of Jerusalem
Israeli geneticists