Arachidonylcyclopropylamide (ACPA) is a synthetic agonist of the

cannabinoid receptor 1 Cannabinoid receptor 1 (CB1), is a G protein-coupled cannabinoid receptor that in humans is encoded by the ''CNR1'' gene. And discovered, by determination and characterization in 1988, and cloned in 1990 for the first time. The human CB1 recep ...

(CB1R). ACPA is considered to be a selective cannabinoid

agonist An agonist is a chemical that activates a Receptor (biochemistry), receptor to produce a biological response. Receptors are Cell (biology), cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an R ...

as it binds primarily to the CB1R and has low affinity to the

cannabinoid receptor 2 The cannabinoid receptor 2 (CB2), is a G protein-coupled receptor from the cannabinoid receptor family that in humans is encoded by the ''CNR2'' gene. It is closely related to the cannabinoid receptor 1 (CB1), which is largely responsible for ...

(CB2R) ( K_i = 2.2 nM for CB1R; K_i = 700 nM for CB2R).

References

{{Cannabinoids Fatty acid amides Cannabinoids Cyclopropyl compounds Arachidonyl compounds