The Anti-apoptotic Ras signaling cascade is an intracellular
signal transduction
Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events, most commonly protein phosphorylation catalyzed by protein kinases, which ultimately results in a cellular ...
cascade
that involves the
Ras protein and inhibits
apoptosis. It is the target of the cancer drug
gefitinib.
It may refer to the
PI3K/
AKT pathway.
It may refer to the
MAPK/ERK pathway
The MAPK/ERK pathway (also known as the Ras-Raf-MEK-ERK pathway) is a chain of proteins in the cell that communicates a signal from a receptor on the surface of the cell to the DNA in the nucleus of the cell.
The signal starts when a signalin ...
which involves ras and can affect apoptosis.
[http://www.aacrmeetingabstracts.org/cgi/content/abstract/2005/1/972-b "Pathways potentiated by oncogenic Ras to modulate apoptosis induced by anticancer agent FR901228 " 2005]
The anti-apoptotic
STAT pathway does not involve Ras.
See also
*
Ras subfamily
References
External links
Diagram of ras onwards.
Signal transduction
Cell cycle
Apoptosis
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