The ANTH domain is a membrane binding domain that shows weak specificity for
PtdIns(4,5)P2. It was found in
AP180 (homologous to CALM) endocytotic accessory protein that has been implicated in the formation of clathrin-coated pits. The domain is involved in phosphatidylinositol 4,5-bisphosphate binding and is a universal adaptor for nucleation of clathrin coats.
Its structure is a solenoid of 9 helices. The PtdIns(4,5)P2 binding residues are spread over several helices at the tip of the structure. The PtdIns(4,5)P2 binding sequence is Kx9Kx(K/R)(H/Y).
An ANTH domain is also found in
HIP1 and
HIP1R, and the PtdIns(4,5)P2 binding sequence is conserved.
Human proteins containing this domain
HIP1;
HIP1R;
PICALM;
SNAP91;
References
Further reading
*
External links
* - Calculated spatial position of ANTH domain of CALM protein in membrane
{{DEFAULTSORT:Anth Domain
Protein domains
Peripheral membrane proteins