pathology Pathology is the study of the causes and effects of disease or injury. The word ''pathology'' also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when used in ...

, Anitschkow (or Anichkov) cells are often

cell Cell most often refers to: * Cell (biology), the functional basic unit of life Cell may also refer to: Locations * Monastic cell, a small room, hut, or cave in which a religious recluse lives, alternatively the small precursor of a monastery w ...

s associated with

rheumatic heart disease Rheumatic fever (RF) is an inflammatory disease that can involve the heart, joints, skin, and brain. The disease typically develops two to four weeks after a streptococcal throat infection. Signs and symptoms include fever, multiple painful ...

. Anitschkow cells are enlarged macrophages found within

granuloma A granuloma is an aggregation of macrophages that forms in response to chronic inflammation. This occurs when the immune system attempts to isolate foreign substances that it is otherwise unable to eliminate. Such substances include infectious ...

s (called

Aschoff bodies In medicine, Aschoff bodies are nodules found in the hearts of individuals with rheumatic fever. They result from inflammation in the heart muscle and are characteristic of rheumatic heart disease. These nodules were discovered independently by Lud ...

) associated with the disease. The cells are also called caterpillar cells, as they have an ovoid

nucleus Nucleus ( : nuclei) is a Latin word for the seed inside a fruit. It most often refers to: *Atomic nucleus, the very dense central region of an atom * Cell nucleus, a central organelle of a eukaryotic cell, containing most of the cell's DNA Nucl ...

and chromatin that is condensed toward the center of the nucleus in a wavy rod-like pattern that to some resembles a

caterpillar Caterpillars ( ) are the larva, larval stage of members of the order Lepidoptera (the insect order comprising butterfly, butterflies and moths). As with most common names, the application of the word is arbitrary, since the larvae of sawfly ...

. Larger Anitschkow cells may coalesce to form multinucleated Aschoff giant cells. Anitschkow cells were named after the

Russia Russia (, , ), or the Russian Federation, is a transcontinental country spanning Eastern Europe and Northern Asia. It is the largest country in the world, with its internationally recognised territory covering , and encompassing one-eigh ...

n pathologist Nikolay Anichkov.

Squamous epithelial cell Epithelium or epithelial tissue is one of the four basic types of animal tissue, along with connective tissue, muscle tissue and nervous tissue. It is a thin, continuous, protective layer of compactly packed cells with a little intercellul ...

s with nuclear changes resembling Anitschkow cells have also been observed in

recurrent aphthous stomatitis Recurrence and recurrent may refer to: *''Disease recurrence'', also called relapse *''Eternal recurrence'', or eternal return, the concept that the universe has been recurring, and will continue to recur, in a self-similar form an infinite number ...

iron deficiency anemia Iron-deficiency anemia is anemia caused by a lack of iron. Anemia is defined as a decrease in the number of red blood cells or the amount of hemoglobin in the blood. When onset is slow, symptoms are often vague such as feeling tired, weak, shor ...

, children receiving

chemotherapy Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents or alkylating agents) as part of a standardized chemotherapy regimen. Chemothe ...

, as well as in healthy individuals.

References

{{Cardiovascular system symptoms and signs Chronic rheumatic heart diseases