Octatropine methylbromide ( INN) or anisotropine methylbromide ( USAN), trade names Valpin, Endovalpin, Lytispasm and others, Retrieved on August 31, 2008 through Google Book Search. is a muscarinic antagonist and

antispasmodic An antispasmodic (synonym: spasmolytic) is a pharmaceutical drug or other agent that suppresses muscle spasms. Smooth muscle spasm One type of antispasmodics is used for smooth muscle relaxation, especially in tubular organs of the gastrointestina ...

. It was introduced to the U.S. market in 1963 as an adjunct in the treatment of

peptic ulcer Peptic ulcer disease is when the inner part of the stomach's gastric mucosa (lining of the stomach), the first part of the small intestine, or sometimes the lower esophagus, gets damaged. An ulcer in the stomach is called a gastric ulcer, while ...

, and promoted as being more specific to the

gastrointestinal tract The gastrointestinal tract (GI tract, digestive tract, alimentary canal) is the tract or passageway of the Digestion, digestive system that leads from the mouth to the anus. The tract is the largest of the body's systems, after the cardiovascula ...

than other anticholinergics, although its selectivity was questioned in later studies. Octatropine has been superseded by more effective agents in the treatment of peptic ulcer disease, and is no longer used. It is still sold in some countries in combination with other drugs, such as

phenobarbital Phenobarbital, also known as phenobarbitone or phenobarb, sold under the brand name Luminal among others, is a medication of the barbiturate type. It is recommended by the World Health Organization (WHO) for the treatment of certain types of ...

and metamizole.

References

Muscarinic antagonists Tropanes Carboxylate esters Quaternary ammonium compounds Antispasmodics {{gastrointestinal-drug-stub