Andrew Jeremy Wakefield (born 3 September 1956
) is a British
fraud
In law, fraud is intent (law), intentional deception to deprive a victim of a legal right or to gain from a victim unlawfully or unfairly. Fraud can violate Civil law (common law), civil law (e.g., a fraud victim may sue the fraud perpetrato ...
ster,
anti-vaccine
Anti-vaccine activism, which collectively constitutes the "anti-vax" movement, is a set of organized activities expressing opposition to vaccination, and these Social networking, collaborating networks have often sought to increase vaccine h ...
activist, and disgraced former physician. He was
struck off the medical register for "serious professional misconduct"
due to his involvement in the fraudulent 1998
''Lancet'' MMR autism study that falsely claimed a link between the
measles, mumps, and rubella (MMR) vaccine and
autism
Autism, also known as autism spectrum disorder (ASD), is a neurodevelopmental disorder characterized by differences or difficulties in social communication and interaction, a preference for predictability and routine, sensory processing d ...
.
The publicity surrounding the study caused a sharp decline in vaccination uptake, leading to a number of outbreaks of
measles
Measles (probably from Middle Dutch or Middle High German ''masel(e)'', meaning "blemish, blood blister") is a highly contagious, Vaccine-preventable diseases, vaccine-preventable infectious disease caused by Measles morbillivirus, measles v ...
around the world and many deaths therefrom. He was a surgeon on the liver transplant programme at the
Royal Free Hospital in
London
London is the Capital city, capital and List of urban areas in the United Kingdom, largest city of both England and the United Kingdom, with a population of in . London metropolitan area, Its wider metropolitan area is the largest in Wester ...
, and became a senior lecturer and honorary consultant in experimental
gastroenterology
Gastroenterology (from the Greek gastḗr- "belly", -énteron "intestine", and -logía "study of") is the branch of medicine focused on the digestive system and its disorders. The digestive system consists of the gastrointestinal tract, sometime ...
at the
Royal Free and University College School of Medicine. He resigned from his positions there in 2001 "by mutual agreement", then moved to the United States. In 2004, Wakefield co-founded and began working at the Thoughtful House research centre (later renamed the Johnson Center for Child Health and Development) in
Austin, Texas
Austin ( ) is the List of capitals in the United States, capital city of the U.S. state of Texas. It is the county seat and most populous city of Travis County, Texas, Travis County, with portions extending into Hays County, Texas, Hays and W ...
. He served as executive director of the centre until February 2010, when he resigned in the wake of findings against him by the British
General Medical Council
The General Medical Council (GMC) is a public body that maintains the official register of physician, medical practitioners within the United Kingdom. Its chief responsibility is to "protect, promote and maintain the health and safety of the pu ...
which had struck him off their register. He has subsequently become known for his
anti-vaccination activism.
Wakefield published his 1998 paper on autism in the British medical journal ''
The Lancet
''The Lancet'' is a weekly peer-reviewed general medical journal, founded in England in 1823. It is one of the world's highest-impact academic journals and also one of the oldest medical journals still in publication.
The journal publishes ...
'', claiming to have identified a novel form of
enterocolitis
Enterocolitis is an inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon. It may be caused by various infections, with bacteria, viruses, fungi, parasites, or other causes. Common clinical mani ...
linked to autism. However, other researchers were unable to
reproduce
Reproduction (or procreation or breeding) is the biological process by which new individual organisms – "offspring" – are produced from their "parent" or parents. There are two forms of reproduction: asexual and sexual.
In asexual reprod ...
his findings,
and a 2004 investigation by ''
Sunday Times
''The Sunday Times'' is a British Sunday newspaper whose circulation makes it the largest in Britain's quality press market category. It was founded in 1821 as ''The New Observer''. It is published by Times Newspapers Ltd, a subsidiary of N ...
'' reporter
Brian Deer identified undisclosed financial
conflicts of interest
A conflict of interest (COI) is a situation in which a person or organization is involved in multiple interests, financial or otherwise, and serving one interest could involve working against another. Typically, this relates to situations in whi ...
on Wakefield's part. Wakefield reportedly stood to earn up to $43 million per year selling test kits.
[ Most of Wakefield's co-authors then withdrew their support for the study's interpretations, and the General Medical Council (GMC) conducted an inquiry into allegations of ]misconduct
Misconduct is wrongful, improper, or unlawful conduct motivated by premeditated or intentional purpose or by obstinate indifference to the consequences of one's acts. It is an act which is forbidden or a failure to do that which is required. Misc ...
against Wakefield and two former colleagues, focusing on Deer's findings.
In 2010, the GMC found that Wakefield had been dishonest in his research, had acted against his patients' best interests, mistreated developmentally delayed children, and had "failed in his duties as a responsible consultant". ''The Lancet'' fully retracted Wakefield's 1998 publication on the basis of the GMC's findings, noting that elements of the manuscript had been falsified and that the journal had been "deceived" by Wakefield. Three months later, Wakefield was struck off the UK medical register, in part for his deliberate falsification of research published in ''The Lancet''. In a related legal decision, a British court held that " ere is now no respectable body of opinion which supports akefield'shypothesis, that MMR vaccine and autism/enterocolitis are causally linked".
In 2016, Wakefield directed the anti-vaccination film '' Vaxxed: From Cover-Up to Catastrophe''.
Early life and education
Wakefield was born on 3 September 1956, to Graham Wakefield, a neurologist, and Bridget d'Estouteville Matthews, a general practitioner, at the Canadian Red Cross Memorial Hospital in Taplow, England.[ As a student at the independent ]King Edward's School, Bath
King Edward's School (KES), in Bath, Somerset, England, is a Private schools in the United Kingdom, private co-educational day school providing education for 1,134 pupils aged 3 to 18.
The school is a member of The Headmasters' and Headmistresses ...
, he was captain of his local rugby team.
After leaving King Edward's School, Wakefield studied medicine at St Mary's Hospital Medical School (now Imperial College School of Medicine
Imperial College School of Medicine (ICSM) is the undergraduate medical school of Imperial College London in England and one of the United Hospitals. It is part of the college's Imperial College Faculty of Medicine, Faculty of Medicine and was ...
), fully qualifying in 1981.
Wakefield became a fellow of the Royal College of Surgeons
The Royal College of Surgeons is an ancient college (a form of corporation) established in England to regulate the activity of surgeons. Derivative organisations survive in many present and former members of the Commonwealth. These organisations ...
in 1985.
Career
At the University of Toronto
The University of Toronto (UToronto or U of T) is a public university, public research university whose main campus is located on the grounds that surround Queen's Park (Toronto), Queen's Park in Toronto, Ontario, Canada. It was founded by ...
from 1986 to 1989, he was a member of a team that studied tissue rejection problems with small intestine
The small intestine or small bowel is an organ (anatomy), organ in the human gastrointestinal tract, gastrointestinal tract where most of the #Absorption, absorption of nutrients from food takes place. It lies between the stomach and large intes ...
transplantation, using animal models. He continued his studies of small intestine transplantation under a Wellcome Trust
The Wellcome Trust is a charitable foundation focused on health research based in London, United Kingdom. It was established in 1936 with legacies from the pharmaceutical magnate Henry Wellcome (founder of Burroughs Wellcome, one of the predec ...
travelling fellowship at University of Toronto in Canada.
In the late 1980s, Wakefieldafter returning to the UKfocused on research. He joined the Royal Free Hospital in London in the 1990s and remained there until his resignation in 2001. He was part of a team at the Royal working on inflammatory bowel disease
Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the colon and small intestine, with Crohn's disease and ulcerative colitis (UC) being the principal types. Crohn's disease affects the small intestine and large intestine ...
from 1995 to 1998.
Following his resignation from Royal Free, Wakefield moved to the United States, where he co-founded the Thoughtful House research centre in Austin, Texas. He served as the executive director of Thoughtful House, which studies autism, and continued to promote the theory of a link between the MMR vaccine and autism, despite admitting it was "not proved."
In February 2010, Wakefield resigned as the executive director of Thoughtful House after the British General Medical Council
The General Medical Council (GMC) is a public body that maintains the official register of physician, medical practitioners within the United Kingdom. Its chief responsibility is to "protect, promote and maintain the health and safety of the pu ...
(GMC) concluded that he had engaged in unethical and dishonest conduct during his research. The GMC found that he had been "dishonest and irresponsible" in conducting his earlier autism research in England.
''The Times'' reported in May 2010 that he was a medical advisor for Visceral, a UK charity that "researches bowel disease and developmental disorders".[
Wakefield has set up the non-profit Strategic Autism Initiative to commission studies into the condition, and in 2013 was listed as a director of a company called Medical Interventions for Autism and another called the Autism Media Channel.]
Although initially supported by Donald Trump, who appeared with him in inauguration photos, the emergence of a measles epidemic led Trump to reconsider his stance. Subsequently, social media platforms provided Wakefield with a fresh avenue to promote his anti-vaccination campaign, resulting in global repercussions, despite the fact that he has never directly treated a patient.
Wakefield directed the anti-vaccination film " Vaxxed: From Cover-Up to Catastrophe" in 2016 which was removed from the Tribeca Film Festival by one of its co-founders, Robert De Niro
Robert Anthony De Niro ( , ; born August 17, 1943) is an American actor, director, and film producer. He is considered to be one of the greatest and most influential actors of his generation. De Niro is the recipient of List of awards and ...
, whose son is on the autism spectrum.
According to a 2020 article in ''The Telegraph'', Wakefield had become prominent in the anti-vaccine movement and during the COVID-19 pandemic
The COVID-19 pandemic (also known as the coronavirus pandemic and COVID pandemic), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), began with an disease outbreak, outbreak of COVID-19 in Wuhan, China, in December ...
, promoted his discredited claims about vaccine safety. He appeared at summits warning that vaccines "will kill us" and called for widespread protests against their use.
In a 2025 interview with ''Democracy Now'', investigative journalist Brian Deer identified Robert F. Kennedy Jr., Andrew Wakefield, and Del Bigtree as the core leaders of the anti-vaccine movement. During the interview, Deer offered his perspective on the Senate confirmation hearings for Kennedy Jr., specifically addressing the questioning by senators Bernie Sanders
Bernard Sanders (born September8, 1941) is an American politician and activist who is the Seniority in the United States Senate, senior United States Senate, United States senator from the state of Vermont. He is the longest-serving independ ...
and Bill Cassidy
William Morgan Cassidy (born September 28, 1957) is an American physician and politician serving as the Seniority in the United States Senate, senior United States senator from Louisiana, a seat he has held since 2015. A member of the Republic ...
regarding Kennedy's alignment with Wakefield's discredited theory linking vaccines to autism.
Claims of measles virus–Crohn's disease link
Back in the UK, he worked on the liver transplant programme at the Royal Free Hospital in London. In 1993, Wakefield attracted professional attention when he published reports in which he concluded that measles virus might cause Crohn's disease
Crohn's disease is a type of inflammatory bowel disease (IBD) that may affect any segment of the gastrointestinal tract. Symptoms often include abdominal pain, diarrhea, fever, abdominal distension, and weight loss. Complications outside of the ...
; and two years later he published a paper in ''The Lancet
''The Lancet'' is a weekly peer-reviewed general medical journal, founded in England in 1823. It is one of the world's highest-impact academic journals and also one of the oldest medical journals still in publication.
The journal publishes ...
'' proposing a link between the measles vaccine and Crohn's disease. Subsequent research failed to confirm this hypothesis, with a group of experts in Britain reviewing a number of peer-reviewed studies in 1998 and concluding that the measles virus did not cause Crohn's disease, and neither did the MMR vaccine.
Later, in 1995, while conducting research into Crohn's disease, he was approached by Rosemary Kessick, the parent of a child with autism, who was seeking help with her son's bowel problems and autism; Kessick ran a group called Allergy Induced Autism. In 1996, Wakefield turned his attention to researching possible connections between the MMR vaccine and autism.
At the time of his MMR research study, Wakefield was senior lecturer and honorary consultant
A consultant (from "to deliberate") is a professional (also known as ''expert'', ''specialist'', see variations of meaning below) who provides advice or services in an area of specialization (generally to medium or large-size corporations). Cons ...
in experimental gastroenterology
Gastroenterology (from the Greek gastḗr- "belly", -énteron "intestine", and -logía "study of") is the branch of medicine focused on the digestive system and its disorders. The digestive system consists of the gastrointestinal tract, sometime ...
at the Royal Free Hospital School of Medicine (from 2008, UCL Medical School). He resigned in 2001, by "mutual agreement and was made a fellow of the Royal College of Pathologists",[ and moved to the US in 2001] (or 2004, by another account). He was reportedly asked to leave the Royal Free Hospital after refusing a request to validate his 1998 ''Lancet'' paper with a controlled study.[
Wakefield is barred from practising as a physician in the UK,][ and is not licensed in the US. He lives in the US where he has a following, including the anti-vaccinationist Jenny McCarthy,][ who wrote the foreword for Wakefield's autobiography, ''Callous Disregard''. She has a son with autism-like symptoms that she believes were caused by the MMR vaccine.] According to Deer, , Wakefield lives near Austin with his family.
''The Lancet'' fraud
On 28 February 1998, Wakefield was the lead author of a study of twelve children with autism that was published in ''The Lancet''. The study proposed a new syndrome
A syndrome is a set of medical signs and symptoms which are correlated with each other and often associated with a particular disease or disorder. The word derives from the Greek language, Greek σύνδρομον, meaning "concurrence". When a sy ...
called autistic enterocolitis, and raised the possibility of a link between a novel form of bowel disease, autism, and the MMR vaccine. The authors said that the parents of eight of the twelve children linked what were described as "behavioural symptoms" with MMR, and reported that the onset of these symptoms began within two weeks of MMR vaccination.
These possible triggers were reported as MMR in eight cases, and measles infection in one. The paper was instantly controversial, leading to widespread publicity in the UK and the convening of a special panel of the UK's Medical Research Council the following month. One 2005 study in Japan found that there was no causal relationship between the MMR vaccine and autism in groups of children given the triple MMR vaccine and children who received individual measles, mumps and rubella vaccinations. In Japan, the MMR vaccine had been replaced with individual vaccinations in 1993.
Although the paper said that no causal connection had been proven, before it was published, Wakefield made statements at a press conference and in a video news release issued by the hospital, calling for suspension of the triple MMR vaccine until more research could be done. This was later criticized as ' science by press conference'. According to BBC News
BBC News is an operational business division of the British Broadcasting Corporation (BBC) responsible for the gathering and broadcasting of news and current affairs in the UK and around the world. The department is the world's largest broad ...
, it was this press conference, rather than the paper in ''The Lancet'', that fuelled the MMR vaccination scare.[ The BBC report said he told journalists: "it was a 'moral issue' and he could no longer support the continued use of the three-in-one jab for measles, mumps and rubella. 'Urgent further research is needed to determine whether MMR may give rise to this complication in a small number of people,' Wakefield said at the time."] He said, "If you give three viruses together, three live viruses, then you potentially increase the risk of an adverse event occurring, particularly when one of those viruses influences the immune system in the way that measles does."[ He suggested parents should opt for single vaccinations against measles, mumps and rubella, separated by gaps of one year. '']60 Minutes
''60 Minutes'' is an American television news magazine broadcast on the CBS television network. Debuting in 1968, the program was created by Don Hewitt and Bill Leonard, who distinguished it from other news programs by using a unique style o ...
'' interviewed him in November 2000, and he repeated these claims to the U.S. audience, providing a new focus for the nascent anti-vaccination movement in the U.S., which had been primarily concerned about thiomersal
Thiomersal (International Nonproprietary Name, INN), or thimerosal (United States Adopted Name, USAN, Japanese Accepted Name, JAN), also sold under the name merthiolate, is an organomercury compound. It is a well-established antiseptic and antif ...
in vaccines.
In November 2001, Wakefield resigned from the Royal Free Hospital, saying, "I have been asked to go because my research results are unpopular." The medical school said that he had left "by mutual agreement". In February 2002, Wakefield stated: "What precipitated this crisis was the removal of the single vaccine, the removal of choice, and that is what has caused the furore—because the doctors, the gurus, are treating the public as though they are some kind of moronic mass who cannot make an informed decision for themselves."
Aftermath of initial controversy
Wakefield continued to conduct clinical research in the United States after leaving the Royal Free Hospital in December 2001. He joined a controversial American researcher, Jeff Bradstreet, at the International Child Development Resource Center, to conduct further studies on the possible relationship between the MMR vaccine and autism.
In 2004, Wakefield began working at the Thoughtful House research centre in Austin, Texas. Wakefield served as executive director of Thoughtful House until February 2010, when he resigned in the wake of findings against him by the British General Medical Council
The General Medical Council (GMC) is a public body that maintains the official register of physician, medical practitioners within the United Kingdom. Its chief responsibility is to "protect, promote and maintain the health and safety of the pu ...
.
In February 2004, the controversy resurfaced when Wakefield was accused of a conflict of interest. In ''The Sunday Times
''The Sunday Times'' is a British Sunday newspaper whose circulation makes it the largest in Britain's quality press market category. It was founded in 1821 as ''The New Observer''. It is published by Times Newspapers Ltd, a subsidiary of N ...
'', Brian Deer reported that some of the parents of the 12 children in the study in ''The Lancet'' were recruited via a UK lawyer preparing a lawsuit against MMR manufacturers, and that the Royal Free Hospital had received £55,000 from the UK's Legal Aid Board (now the Legal Services Commission
The Legal Services Commission (LSC) was an executive non-departmental public body of the Ministry of Justice (United Kingdom), Ministry of Justice which was responsible for the operational administration of legal aid in England and Wales between ...
) to pay for the research. Previously, in October 2003, the board had cut off public funding for the litigation against MMR manufacturers. Following an investigation of the allegations in ''The Sunday Times'' by the UK General Medical Council, Wakefield was charged with serious professional misconduct, including dishonesty. In December 2006, Deer, writing in ''The Sunday Times'', further reported that in addition to the money they donated to the Royal Free Hospital, the lawyers responsible for the MMR lawsuit had paid Wakefield personally more than £400,000, which he had not previously disclosed.
Twenty-four hours before the 2004 ''Sunday Times'' report by Deer, ''The Lancet''s editor Richard Horton responded to the investigation in a public statement, describing Wakefield's research as "fatally flawed" and said he believed the paper would have been rejected as biased if the peer reviewers had been aware of Wakefield's conflict of interest. Ten of Wakefield's twelve co-authors of the paper in ''The Lancet'' later published a retraction of an interpretation. The section of the paper retracted read as follows:
The retraction stated:[
]
''Wakefield v Channel 4 Television and Others''
In November 2004, Channel 4
Channel 4 is a British free-to-air public broadcast television channel owned and operated by Channel Four Television Corporation. It is state-owned enterprise, publicly owned but, unlike the BBC, it receives no public funding and is funded en ...
broadcast a one-hour '' Dispatches'' investigation by reporter Brian Deer; the ''Toronto Star'' said Deer had "produced documentary evidence that Wakefield applied for a patent on a single-jab measles vaccine before his campaign against the MMR vaccine, raising questions about his motives".
In addition to Wakefield's unpublished initial patent submission,[ Deer released a copy of the published patent application. At page 1, the first paragraph of this stated:
Before describing the research in Wakefield's 1998 paper in ''The Lancet'', at the same page this patent explicitly states that the use of the MMR vaccine causes autism:
According to Deer, a letter from Wakefield's lawyers to him dated 31 January 2005 said: "Dr Wakefield did not plan a rival vaccine."][
In the ''Dispatches'' programme, Deer also revealed that Nicholas Chadwick, a researcher working under Wakefield's supervision in the Royal Free medical school, had failed to find measles virus in the children reported on in ''The Lancet''.
In January 2005, Wakefield initiated libel proceedings against Channel 4, the independent production company Twenty Twenty and Brian Deer, ''The Sunday Times'', and against Deer personally along with his website briandeer.com] in the case ''Wakefield v Channel Four Television and Others'' 006
Alec Trevelyan is a fictional character who is the main antagonist in the 1995 James Bond film ''GoldenEye,'' portrayed by actor Sean Bean. Bean's likeness was also used as the model for Alec Trevelyan in the 1997 video game '' GoldenEye 007' ...
EWHC 3289 (QB); 007
The ''James Bond'' franchise focuses on James Bond (literary character), the titular character, a fictional Secret Intelligence Service, British Secret Service agent created in 1953 by writer Ian Fleming, who featured him in twelve novels ...
94 BMLR 1. Within weeks of issuing his claims, however, Wakefield sought to have the action frozen until after the conclusion of General Medical Council proceedings against him. Channel 4 and Deer sought a High Court order compelling Wakefield to continue with his action, or discontinue it. After a hearing on 27 and 28 October 2005, Justice David Eady ruled against a stay of proceedings
A stay of proceedings is a ruling by the court in civil and criminal procedure that halts further legal process in a trial or other legal proceeding. The court can subsequently lift the stay and resume proceedings based on events taking place ...
:
The judgment identified Channel 4's "very lengthy extracts" summarizing Deer's allegations against Wakefield:[
:(i) akefieldspread fear that the MMR vaccine might lead to autism, even though he knew that his own laboratory had carried out tests whose results dramatically contradicted his claims in that the measles virus had not been found in a single one of the children concerned in his study and he knew or ought to have known that there was absolutely no basis at all for his belief that the MMR should be broken up into single vaccines.
:(ii) In spreading such fear, acted dishonestly and for mercenary motives in that, although he improperly failed to disclose the fact, he planned a rival vaccine and products (such as a diagnostic kit based on his theory) that could have made his fortune
:(iii) Gravely abused the children under his care by unethically carrying out extensive invasive procedures (on occasions requiring three people to hold a child down), thereby driving nurses to leave and causing his medical colleagues serious concern and unhappiness
:(iv) Improperly and/or dishonestly failed to disclose to his colleagues and to the public that his research on autistic children had begun with a contract with solicitors who were trying to sue the manufacturers of the MMR vaccine
:(v) Improperly or dishonestly lent his reputation to the International Child Development Resource Centre, which promoted to very vulnerable parents expensive products for whose efficacy (as he knew or should have known) there was no scientific evidence
Eady's ruling states that, "The views or conclusions of the GMC disciplinary body would not, so far as I can tell, be relevant or admissible", that Channel 4's allegations "go to undermine fundamentally the Claimant's professional integrity and honesty", and that, "It cannot seriously be suggested that priority should be given to GMC proceedings for the resolution of issues."
In December 2006, Deer released records obtained from the Legal Services Commission, showing that it had paid £435,643 in undisclosed fees to Wakefield for the purpose of building a case against the MMR vaccine. Those payments, ''The Sunday Times'' reported, had begun two years before publication of Wakefield's paper in ''The Lancet''.] Within days of Deer's report, Wakefield dropped all his libel actions and was ordered to pay all defendants' legal costs.
Other concerns
Wakefield's data was also questioned; a former graduate student, who appeared in Deer's programme, later testified that Wakefield ignored laboratory data that conflicted with his hypothesis. An independent investigation of a collaborating laboratory questioned the accuracy of the data underpinning Wakefield's claims.
In June 2005, the BBC
The British Broadcasting Corporation (BBC) is a British public service broadcaster headquartered at Broadcasting House in London, England. Originally established in 1922 as the British Broadcasting Company, it evolved into its current sta ...
programme ''Horizon
The horizon is the apparent curve that separates the surface of a celestial body from its sky when viewed from the perspective of an observer on or near the surface of the relevant body. This curve divides all viewing directions based on whethe ...
'' reported on an unnamed and unpublished study of blood samples from a group of 100 autistic children and 200 children without autism. They reported finding 99% of the samples contained no trace of the measles virus, and the samples that did contain the virus were just as likely to be from non-autistic children, i.e., only three samples contained the measles virus, one from an autistic child and two from a typically developing child. The study's authors found no evidence of any link between MMR and autism.
The Institute of Medicine
The National Academy of Medicine (NAM), known as the Institute of Medicine (IoM) until 2015, is an American nonprofit, non-governmental organization. The National Academy of Medicine is a part of the National Academies of Sciences, Engineerin ...
(IOM) of the United States National Academy of Sciences
The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Nati ...
, along with the CDC
The Centers for Disease Control and Prevention (CDC) is the national public health agency of the United States. It is a United States federal agency under the Department of Health and Human Services (HHS), and is headquartered in Atlanta, ...
and the UK National Health Service
The National Health Service (NHS) is the term for the publicly funded health care, publicly funded healthcare systems of the United Kingdom: the National Health Service (England), NHS Scotland, NHS Wales, and Health and Social Care (Northern ...
, have found no link between vaccines and autism. Reviews in the medical literature have also found no link between the MMR vaccine and autism or with bowel disease, which Wakefield called " autistic enterocolitis".
General Medical Council hearings
Between July 2007 and May 2010, a 217-day "fitness to practise" hearing of the UK General Medical Council examined charges of professional misconduct
Professional ethics encompass the personal and corporate standards of behavior expected of professionals.
The word professionalism originally applied to vows of a religious order. By no later than the year 1675, the term had seen secular appli ...
against Wakefield and two colleagues involved in the paper in ''The Lancet''. The charges included that he:
* "Was being paid to conduct the study by solicitors representing parents who believed their children had been harmed by MMR".[
* Ordered investigations "without the requisite paediatric qualifications" including colonoscopies, colon biopsies and lumbar punctures ("spinal taps") on his research subjects without the approval of his department's ethics board and contrary to the children's clinical interests,][ when these diagnostic tests were not indicated by the children's symptoms or medical history.
* "Act d'dishonestly and irresponsibly' in failing to disclose ... how patients were recruited for the study"][ as well as in his descriptions in the ''Lancet'' papers and in questions after the paper published, about what ailments the children had, and when those ailments were observed relative to their getting vaccinated.
* "Conduct dthe study on a basis not approved by the hospital's ethics committee."][
* Purchased blood samples—for £5 each—from children present at his son's birthday party, which Wakefield joked about in a later presentation.][
* " owed callous disregard for any distress or pain the children might suffer"][
Wakefield denied the charges; on 28 January 2010, the GMC ruled against Wakefield on all issues, stating that he had "failed in his duties as a responsible consultant",] acted against the interests of his patients, and "dishonestly and irresponsibly" in his controversial research. On 24 May 2010, he was struck off the United Kingdom medical register. It was the harshest sanction that the GMC could impose, and effectively ended his career as a physician. In announcing the ruling, the GMC said that Wakefield had "brought the medical profession into disrepute", and no sanction short of erasing his name from the register was appropriate for the "serious and wide-ranging findings" of misconduct.[ On the same day, Wakefield's autobiography, ''Callous Disregard'' was published, using the same words as one of the charges against him ("he showed callous disregard for any distress or pain the children might suffer").][ Wakefield argued that he had been unfairly treated by the medical and scientific establishment.
]
Fraud and conflict of interest allegations
In February 2009, ''The Sunday Times'' reported that a further investigation by the newspaper had revealed that Wakefield "changed and misreported results in his research, creating the appearance of a possible link with autism", citing evidence obtained by the newspaper from medical records and interviews with witnesses, and supported by evidence presented to the GMC.
In April 2010, Deer expanded on laboratory aspects of his findings in a report in the '' BMJ'', recounting how normal clinical histopathology
Histopathology (compound of three Greek words: 'tissue', 'suffering', and '' -logia'' 'study of') is the microscopic examination of tissue in order to study the manifestations of disease. Specifically, in clinical medicine, histopatholog ...
results (obtained from the Royal Free hospital) had been subjected to wholesale changes, from normal to abnormal, in the medical school and published in ''The Lancet''. On 2 January 2011, Deer provided two tables comparing the data on the twelve children, showing the original hospital data and the data with the wholesale changes as used in the 1998 ''The Lancet'' article.
On 5 January 2011, ''BMJ'' published an article by Brian Deer entitled "How the case against the MMR vaccine was fixed".[ Deer said that, based on examination of the medical records of the 12 children in the original study, his research had found:]
In an accompanying editorial, ''BMJ'' editors said:
The ''British Medical Journal
''The BMJ'' is a fortnightly peer-reviewed medical journal, published by BMJ Publishing Group Ltd, which in turn is wholly-owned by the British Medical Association (BMA). ''The BMJ'' has editorial freedom from the BMA. It is one of the world ...
'' editorial concluded that Wakefield's paper was an "elaborate fraud".
In a ''BMJ'' follow-up article on 11 January 2011, Deer stated that Wakefield had planned to capitalize on the MMR vaccination scare provoked by his paper. He said that based upon documents he had obtained under Freedom of information legislation
Freedom of information laws allow access by the general public to data held by national governments and, where applicable, by state and local governments. The emergence of freedom of information legislation was a response to increasing dissatis ...
, Wakefield—in partnership with the father of one of the boys in the study—had planned to launch a venture on the back of an MMR vaccination scare that would profit from new medical tests and "litigation driven testing". ''The Washington Post
''The Washington Post'', locally known as ''The'' ''Post'' and, informally, ''WaPo'' or ''WP'', is an American daily newspaper published in Washington, D.C., the national capital. It is the most widely circulated newspaper in the Washington m ...
'' reported that Deer said that Wakefield predicted he "could make more than $43 million a year from diagnostic kits" for the new condition, autistic enterocolitis.[ According to Deer's report in ''BMJ'', the ventures, Immunospecifics Biotechnologies Ltd and Carmel Healthcare Ltd—named after Wakefield's wife—failed after Wakefield's superiors at University College London's medical school gave him a two-page letter that said:
]WebMD
WebMD is an American corporation which publishes online news and information about human health and well-being. The WebMD website also includes information about drugs and is an important healthcare information website and the most popular cons ...
reported on Deer's ''BMJ'' report, saying that the $43 million predicted yearly profits would come from marketing kits for "diagnosing patients with autism" and that "the initial market for the diagnostic will be litigation-driven testing of patients with AE utistic enterocolitis, an unproven condition concocted by Wakefieldfrom both the UK and the US". According to WebMD, the ''BMJ'' article also claimed that Carmel Healthcare Ltd. would succeed in marketing products and developing a replacement vaccine if "public confidence in the MMR vaccine ere
Ere or ERE may refer to:
* ''Environmental and Resource Economics'', a peer-reviewed academic journal
* ERE Informatique, one of the first French video game companies
* Ere language, an Austronesian language
* Ebi Ere (born 1981), American-Nigeria ...
damaged".[
In October 2012, research published in PNAS, the Proceedings of the National Academy of Sciences, identified Wakefield's 1998 paper as the most cited retracted scientific paper, with 758 citations, and gave the "reason for retraction" as "fraud".]
Journal retractions
On 2 February 2010, ''The Lancet'' formally retracted Wakefield's 1998 paper. The retraction states: "The claims in the original paper that children were 'consecutively referred' and that investigations were 'approved' by the local ethics committee have been proven to be false."
The following day, the editor of a specialist journal, '' NeuroToxicology'', withdrew another Wakefield paper that was in press. The article, which concerned research on monkeys, had already been published online and sought to implicate vaccines in autism.
In May 2010, '' The American Journal of Gastroenterology'' retracted a paper of Wakefield's that used data from the 12 patients of the article in ''The Lancet''.
On 5 January 2011, ''British Medical Journal'' editors recommended that Wakefield's other publications be scrutinized and retracted if need be.
Wakefield response
As of January 2011, Wakefield continued to maintain his innocence. In a press release, he stated,
In an Internet radio interview, Wakefield said the ''BMJ'' series "was utter nonsense" and denied "that he used the cases of the 12 children in his study to promote his business venture". Deer has filed financial disclosure forms and rejects Wakefield's claim that he is funded by the pharmaceutical industry. According to CNN
Cable News Network (CNN) is a multinational news organization operating, most notably, a website and a TV channel headquartered in Atlanta. Founded in 1980 by American media proprietor Ted Turner and Reese Schonfeld as a 24-hour cable ne ...
, Wakefield said the patent he held was for "an 'over-the-counter nutritional supplement' that boosts the immune system". WebMD reported that Wakefield said he was the victim of "a ruthless, pragmatic attempt to crush any attempt to investigate valid vaccine safety concerns".[
Wakefield says that Deer is a "hit man who was brought in to take imdown" and that other scientists have simply taken Deer at his word. While on '']Anderson Cooper 360°
''Anderson Cooper 360°'' (commonly shortened to either ''AC-360'' or ''360'') is an American television news show on CNN and CNN International, hosted by CNN journalist and news anchor Anderson Cooper. Current segments include ‘Reality Check ...
'', he said that he had not read the ''BMJ'' articles yet, but he denied their validity and denied that Deer had interviewed the families of the children in the study. He also urged viewers to read his book, ''Callous Disregard'', which he said would explain why he was being targeted, to which Anderson Cooper
Anderson Hays Cooper (born June 3, 1967) is an American broadcast journalist and political commentator who anchors the CNN news broadcast show ''Anderson Cooper 360°''. In addition to his duties at CNN, Cooper serves as a correspondent for ''6 ...
replied: "But sir, if you're lying, then your book is also a lie. If your study is a lie, your book is a lie."
Wakefield later implied that there is a conspiracy
A conspiracy, also known as a plot, ploy, or scheme, is a secret plan or agreement between people (called conspirers or conspirators) for an unlawful or harmful purpose, such as murder, treason, or corruption, especially with a political motivat ...
by public health
Public health is "the science and art of preventing disease, prolonging life and promoting health through the organized efforts and informed choices of society, organizations, public and private, communities and individuals". Analyzing the de ...
officials and pharmaceutical companies
The pharmaceutical industry is a Medicine, medical industry that discovers, develops, produces, and markets pharmaceutical goods such as medications and medical devices. Medications are then administered to (or Self-medicate, self-administered b ...
to discredit him, including suggesting they pay bloggers to post rumours about him on websites or that they artificially inflated reports of deaths from measles.
Deer counter-response
Deer responded to Wakefield's charge by challenging Wakefield to sue him:
Deer mentioned that all of Wakefield's previous libel actions had been dismissed or withdrawn.[
In January 2012, Wakefield filed a defamation lawsuit in Texas state court against Deer, Fiona Godlee, and the ''BMJ'' for false accusations of fraud, seeking a jury trial in Travis County. The filing identified Wakefield as a resident of Austin, and cited the " Texas Long-Arm Statute" as justification for initiating the proceeding in Texas. The ''BMJ'' responded that it stood by its reports and would "defend the claim vigorously". In August 2012 District Court Judge Amy Meachum dismissed Wakefield's suit for lack of jurisdiction.] Her ruling was upheld on appeal in September 2014 and Wakefield was ordered to pay all parties' costs.
On 5 April 2011, Deer was named the UK's specialist journalist of the year in the British Press Awards
The Press Awards, formerly the British Press Awards, is an annual ceremony that celebrates the best of British journalism.
History
Established in 1962 by ''The People'' and '' World's Press News'', the first award ceremony for the then-named Ha ...
, organised by the Society of Editors
The Society of Editors is an industry body for around 400 UK national and regional media editors, representatives and organisations.
History and organization
The Society has an elected president, chair and board of directors. It was formed b ...
. The judges said that Deer's investigation of Wakefield was a "tremendous righting of a wrong".
Epidemics, effects, and reception
Physicians, medical journals, and editors have made statements tying Wakefield's fraudulent actions to various epidemics and deaths. Michael J. Smith, a professor of pediatrics at the University of Louisville
The University of Louisville (UofL) is a public university, public research university in Louisville, Kentucky, United States. It is part of the Kentucky state university system. Chartered in 1798 as the Jefferson Seminary, it became in the 19t ...
, an "infectious diseases expert who has studied the autism controversy's effect on immunization rates", said, "Clearly, the results of this akefieldstudy have had repercussions."
Wakefield's study and his claim that the MMR vaccine might cause autism led to a decline in vaccination rates in the United States, the United Kingdom, and Ireland, and a corresponding rise in measles
Measles (probably from Middle Dutch or Middle High German ''masel(e)'', meaning "blemish, blood blister") is a highly contagious, Vaccine-preventable diseases, vaccine-preventable infectious disease caused by Measles morbillivirus, measles v ...
and mumps
MUMPS ("Massachusetts General Hospital Utility Multi-Programming System"), or M, is an imperative, high-level programming language with an integrated transaction processing key–value database. It was originally developed at Massachusetts Gen ...
infections, resulting in serious illness and deaths. His continued claims that the vaccine is harmful have contributed to a climate of distrust of all vaccines and the reemergence of other previously controlled diseases.
The Associated Press
The Associated Press (AP) is an American not-for-profit organization, not-for-profit news agency headquartered in New York City.
Founded in 1846, it operates as a cooperative, unincorporated association, and produces news reports that are dist ...
said:
WWAY, an ABC affiliate in Wilmington, North Carolina
Wilmington is a port city in New Hanover County, North Carolina, United States. With a population of 115,451 as of the 2020 United States census, 2020 census, it is the List of municipalities in North Carolina, eighth-most populous city in the st ...
, said:
Paul Hébert, editor-in-chief of the ''Canadian Medical Association Journal
The ''Canadian Medical Association Journal'' (French ''Journal de l'Association Médicale Canadienne'') is a peer-reviewed open-access general medical journal published by the Canadian Medical Association. It publishes original clinical research ...
'' (CMAJ) said:
A profile in a ''New York Times Magazine
''The New York Times Magazine'' is an American Sunday magazine included with the Sunday edition of ''The New York Times''. It features articles longer than those typically in the newspaper and has attracted many notable contributors. The magazin ...
'' article commented:
In January 2011, CNN reported:
On 1 April 2011, the James Randi Educational Foundation
The James Randi Educational Foundation (JREF) is an American grant-making institution founded in 1996 by magician and skeptic James Randi. As a nonprofit organization, the mission of JREF includes educating the public and the media on the dange ...
awarded Wakefield the Pigasus Award
The Pigasus Award is the name of an annual tongue-in-cheek award, which was presented by the late James Randi, a skeptic. The purpose of the award was to expose parapsychological, paranormal, and psychic frauds whom Randi had noted over th ...
for "refusal to face reality".
A 2011 journal article described the vaccine-autism connection as "the most damaging medical hoax of the last 100 years".
In 2011, Wakefield was at the top of the list of the worst doctors of 2011 in ''Medscape
Medscape is a website providing access to medical information for clinicians and medical scientists; the organization also provides continuing education for physicians and other health professionals. It references medical journal articles, Con ...
's'' list of "Physicians of the Year: Best and Worst". In January 2012, ''Time
Time is the continuous progression of existence that occurs in an apparently irreversible process, irreversible succession from the past, through the present, and into the future. It is a component quantity of various measurements used to sequ ...
'' magazine named Wakefield in a list of "Great Science Frauds". In 2012 he was awarded the Lifetime Achievement in Quackery award by the Good Thinking Society.
A writer from ''The New York Times'', who was covering a 2011 event in Tomball, Texas
Tomball ( ) is a city in Harris County, Texas, Harris County in the U.S. state of Texas, a part of the Greater Houston, Houston metropolitan area. The population was 12,341 at the 2020 United States census, 2020 U.S. census. In 1907, the community ...
where Wakefield spoke, was threatened by its organizer, Michelle Guppy: "Be nice to him, or we will hurt you." Guppy is the coordinator of the Houston Autism Disability Network.
In June 2012, a local court in Rimini
Rimini ( , ; or ; ) is a city in the Emilia-Romagna region of Northern Italy.
Sprawling along the Adriatic Sea, Rimini is situated at a strategically-important north-south passage along the coast at the southern tip of the Po Valley. It is ...
, Italy, ruled that the MMR vaccination had caused autism in a 15-month-old boy. The court relied heavily on Wakefield's discredited ''Lancet'' paper and largely ignored the scientific evidence presented to it. The decision was appealed. On 13 February 2015, the decision was overturned by a Court of Appeals in Bologna
Bologna ( , , ; ; ) is the capital and largest city of the Emilia-Romagna region in northern Italy. It is the List of cities in Italy, seventh most populous city in Italy, with about 400,000 inhabitants and 150 different nationalities. Its M ...
.
In February 2015, Wakefield denied that he bore any responsibility for the measles epidemic that started at Disneyland
Disneyland is a amusement park, theme park at the Disneyland Resort in Anaheim, California. It was the first theme park opened by the Walt Disney Company and the only one designed and constructed under the direct supervision of Walt Disney, ...
. He also reaffirmed his discredited belief that "MMR contributes to the current autism epidemic". By that time at least 166 measles cases had been reported. Paul Offit did not agree, saying that the outbreak was "directly related to Dr. Wakefield's theory".
Filmmaker Miranda Bailey followed Wakefield and his wife Carmel and their children for five years filming a documentary about Wakefield as a person, ''The Pathological Optimist''. According to Robert Ladendorf writing for ''Skeptical Inquirer
''Skeptical Inquirer'' (S.I.) is a bimonthly American general-audience magazine published by the Committee for Skeptical Inquiry (CSI) with the subtitle "The Magazine for Science and Reason". The magazine initially focused on investigating clai ...
'' magazine, Bailey attempted to remain neutral and add a "human touch", which Ladendorf says was successful. Wakefield is shown "as a soft-spoken but beleaguered family man trying to resurrect his reputation and raising money for his legal fund."
In 2018, ''The Skeptic'' awarded Wakefield the Rusty Razor award "for pseudoscience and bad critical thinking." The award is decided annually by readers' votes. Editor Deborah Hyde said, "Our contributors clearly felt that anti-vaccination damage is still a current issue, despite Mr. Wakefield first having come to public attention so long ago. These childhood diseases can do real damage, so we're proud to be an organisation that gets the good news out therethe evidence is overwhelming that vaccination is safe. Protect your children and your community by using it."
In 2022, Wakefield's fraudulent study was included on a list of "11 of the biggest lies in history".
Political activism
Wakefield was scheduled to testify before the Oregon Senate Health Care Committee on 9 March 2015, in opposition to Senate Bill 442, "a bill that would eliminate nonmedical exemptions from Oregon's school immunization law". The Oregon Chiropractic Association had invited him. The chairman of the committee then canceled the meeting "after it became clear that" Wakefield planned to testify. She denied that her decision had anything to do with Wakefield's plans.
On 24 April 2015, Wakefield received two standing ovations from the students at Life Chiropractic College West when he told them to oppose Senate Bill 277 (SB 277), a bill that proposes elimination of non-medical vaccine exemptions. Wakefield had previously been a featured speaker at a 2014 "California Jam" gathering of chiropractors, as well as a 2015 "California Jam" seminar, with continuing education
Continuing education is the education undertaken after initial education for either personal or professional reasons. The term is used mainly in the United States and Canada.
Recognized forms of post-secondary learning activities within the d ...
credits, sponsored by Life Chiropractic College West. On 3 July 2015, Wakefield participated in a protest held in Santa Monica, California, against SB 277, a recently enacted bill which removed the personal belief exemption to school vaccine requirements in California state law.
Regarding his anti-vaccine advocacy, Wakefield has been described as a conspiracy theorist
A conspiracy theory is an explanation for an event or situation that asserts the existence of a conspiracy (generally by powerful sinister groups, often political in motivation), when other explanations are more probable.Additional sources:
*
...
by ''ThinkProgress
''ThinkProgress'' was an American Progressivism in the United States, progressive news website that was active from 2005 to 2019. It was a project of the Center for American Progress#Center for American Progress Action Fund, Center for America ...
'', ''The Washington Post
''The Washington Post'', locally known as ''The'' ''Post'' and, informally, ''WaPo'' or ''WP'', is an American daily newspaper published in Washington, D.C., the national capital. It is the most widely circulated newspaper in the Washington m ...
'', ''The Guardian
''The Guardian'' is a British daily newspaper. It was founded in Manchester in 1821 as ''The Manchester Guardian'' and changed its name in 1959, followed by a move to London. Along with its sister paper, ''The Guardian Weekly'', ''The Guardi ...
'', the ''Los Angeles Times
The ''Los Angeles Times'' is an American Newspaper#Daily, daily newspaper that began publishing in Los Angeles, California, in 1881. Based in the Greater Los Angeles city of El Segundo, California, El Segundo since 2018, it is the List of new ...
'', ''Wired
Wired may refer to:
Arts, entertainment, and media Music
* ''Wired'' (Jeff Beck album), 1976
* ''Wired'' (Hugh Cornwell album), 1993
* ''Wired'' (Mallory Knox album), 2017
* "Wired", a song by Prism from their album '' Beat Street''
* "Wired ...
'', the Johns Hopkins Bloomberg School of Public Health
The Johns Hopkins Bloomberg School of Public Health is the public health graduate school of Johns Hopkins University, a private university, private research university primarily based in Baltimore, Maryland.
It was founded as the Johns Hopkins ...
, Steven Salzberg
Steven Lloyd Salzberg (born 1960) is an American computational biologist and computer scientist who is a Bloomberg Distinguished Professor of Biomedical Engineering, Computer Science, and Biostatistics at Johns Hopkins University, where he is al ...
, and Paul Offit.
''Vaxxed'' film
In 2016, Wakefield directed the anti-vaccination propaganda
Propaganda is communication that is primarily used to influence or persuade an audience to further an agenda, which may not be objective and may be selectively presenting facts to encourage a particular synthesis or perception, or using loaded l ...
film ''Vaxxed: From Cover-Up to Catastrophe.'' The film purports to show "an appalling cover-up committed by the government agency charged with protecting the health of American citizens he US Centers for Disease Control and Prevention (CDC)">Centers for Disease Control and Prevention">he US Centers for Disease Control and Prevention (CDC)... an alarming deception that has contributed to the skyrocketing increase of autism and potentially the most catastrophic epidemic of our lifetime." The film was withdrawn from New York's 2016 Tribeca Film Festival after the festival's founder Robert De Niro
Robert Anthony De Niro ( , ; born August 17, 1943) is an American actor, director, and film producer. He is considered to be one of the greatest and most influential actors of his generation. De Niro is the recipient of List of awards and ...
(who has a child with autism) reversed his decision to include it. The film was also scheduled to be projected at the Mairie de Paris but was then moved to a small private cinema. Wakefield called this action censorship. Ian Lipkin, professor of epidemiology and director of the Center for Infection and Immunity at the Columbia University Mailman School of Public Health, writing in ''The Wall Street Journal
''The Wall Street Journal'' (''WSJ''), also referred to simply as the ''Journal,'' is an American newspaper based in New York City. The newspaper provides extensive coverage of news, especially business and finance. It operates on a subscriptio ...
'', said: "If ''Vaxxed'' had been submitted as science fiction, it would merit attention for its story line, character development and dialogue. But as a documentary it misrepresents what science knows about autism, undermines public confidence in the safety and efficacy of vaccines, and attacks the integrity of legitimate scientists and public-health officials".
Selected publications
Books
*
*
Journal articles
* Withdrawn:
* Retracted:
* Retracted:
*
*
*
*
See also
* H. Hugh Fudenberg
* List of scientific misconduct incidents
Notes
References
External links
*
*
*
*
*
* Updated March 2015.
*
{{DEFAULTSORT:Wakefield, Andrew
1956 births
Living people
Academic scandals
Alumni of Imperial College London
Alumni of St Mary's Hospital Medical School
British anti-vaccination activists
Autism pseudoscience
English conspiracy theorists
English fraudsters
Health fraud people
Medical controversies in the United Kingdom
Medical doctors struck off by the General Medical Council
Medical scandals in the United Kingdom
Place of birth missing (living people)
People educated at King Edward's School, Bath
People involved in scientific misconduct incidents
MMR vaccine and autism
English activists