Andrea Musacchio (born July 11, 1964) is an Italian structural biologist. He is Max Planck director at th
Institute of Molecular Physiology
in Dortmund. He is also Honorary Professor at th
Center for Medical Biotechnology
at th
University of Duisburg-Essen
He was named

European Molecular Biology Organization The European Molecular Biology Organization (EMBO) is a professional, non-profit organization of more than 1,800 life scientists. Its goal is to promote research in life science and enable international exchange between scientists. It co-funds cour ...

member in 2009.

Education and career

Musacchio received a

Laurea In Italy, the ''laurea'' is the main post-secondary academic degree. The name originally referred literally to the laurel wreath, since ancient times a sign of honor and now worn by Italian students right after their official graduation ceremon ...

Biology Biology is the scientific study of life. It is a natural science with a broad scope but has several unifying themes that tie it together as a single, coherent field. For instance, all organisms are made up of cells that process hereditar ...

from the

University of Rome Tor Vergata Tor Vergata University of Rome, also known as the University of Rome II ( it, Università degli Studi di Roma "Tor Vergata"), is a public research university located in Rome, Italy. Located in the southeastern suburb of Rome, the university combine ...

''summa'' ''

cum laude Latin honors are a system of Latin phrases used in some colleges and universities to indicate the level of distinction with which an academic degree has been earned. The system is primarily used in the United States. It is also used in some So ...

'' in 1990, and earned his

Ph.D. A Doctor of Philosophy (PhD, Ph.D., or DPhil; Latin: or ') is the most common degree at the highest academic level awarded following a course of study. PhDs are awarded for programs across the whole breadth of academic fields. Because it is a ...

, ''summa'' ''cum laude'', from the

Heidelberg University } Heidelberg University, officially the Ruprecht Karl University of Heidelberg, (german: Ruprecht-Karls-Universität Heidelberg; la, Universitas Ruperto Carola Heidelbergensis) is a public research university in Heidelberg, Baden-Württemberg, ...

in 1995 working at the

European Molecular Biology Laboratory The European Molecular Biology Laboratory (EMBL) is an intergovernmental organization dedicated to molecular biology research and is supported by 27 member states, two prospect states, and one associate member state. EMBL was created in 1974 a ...

. For his

postdoctoral A postdoctoral fellow, postdoctoral researcher, or simply postdoc, is a person professionally conducting research after the completion of their doctoral studies (typically a PhD). The ultimate goal of a postdoctoral research position is to pu ...

studies he joined Stephen C. Harrison laboratory at the

Harvard Medical School Harvard Medical School (HMS) is the graduate medical school of Harvard University and is located in the Longwood Medical and Academic Area, Longwood Medical Area of Boston, Massachusetts. Founded in 1782, HMS is one of the oldest medical schools ...

Boston Boston (), officially the City of Boston, is the capital city, state capital and List of municipalities in Massachusetts, most populous city of the Commonwealth (U.S. state), Commonwealth of Massachusetts, as well as the cultural and financ ...

. In 1999 he returned to Italy to found his laboratory at th
European Institute of Oncology
in

Milan Milan ( , , Lombard language, Lombard: ; it, Milano ) is a city in northern Italy, capital of Lombardy, and the List of cities in Italy, second-most populous city proper in Italy after Rome. The city proper has a population of about 1.4 ...

, where he started working on mechanisms of

cell division Cell division is the process by which a parent cell divides into two daughter cells. Cell division usually occurs as part of a larger cell cycle in which the cell grows and replicates its chromosome(s) before dividing. In eukaryotes, there ar ...

. He was a

Young Investigator from 2000-2004. Musacchio moved to Dortmund in 2011 to direct the Department of Mechanistic Cell Biology at the

Max Planck Institute for Molecular Physiology The Max Planck Institute of Molecular Physiology (german: Max-Planck-Institut für molekulare Physiologie) is located in Dortmund, next to the Dortmund University of Technology. It is one of 80 institutes in the Max Planck Society (Max Planck Ge ...

Research

Musacchio approached structural biology during his

, contributing to the determination of the first crystallographic structures of the SH3 and PH domains. During his post-doctoral training, he was involved in the determination of the

clathrin Clathrin is a protein that plays a major role in the formation of coated vesicles. Clathrin was first isolated and named by Barbara Pearse in 1976. It forms a triskelion shape composed of three clathrin heavy chains and three light chains. Wh ...

triskelion structure, one of the first studies combining

X-ray crystallography X-ray crystallography is the experimental science determining the atomic and molecular structure of a crystal, in which the crystalline structure causes a beam of incident X-rays to diffract into many specific directions. By measuring the angle ...

and

electron microscopy An electron microscope is a microscope that uses a beam of accelerated electrons as a source of illumination. As the wavelength of an electron can be up to 100,000 times shorter than that of visible light photons, electron microscopes have a ...

. As an independent scientist, his interests focused on the understanding of the molecular basis of

mitosis In cell biology, mitosis () is a part of the cell cycle in which replicated chromosomes are separated into two new nuclei. Cell division by mitosis gives rise to genetically identical cells in which the total number of chromosomes is maint ...

, with emphasis on the

spindle assembly checkpoint The spindle checkpoint, also known as the metaphase-to-anaphase transition, the spindle assembly checkpoint (SAC), the metaphase checkpoint, or the mitotic checkpoint, is a cell cycle checkpoint during mitosis or meiosis that prevents the separa ...

. Since the early days, Musacchio's lab adopted a multi-disciplinary approach merging structural biology, biochemistry and cellular biology, this way gaining comprehensive views on protein functions in living cells. He is best known for his work on Mad1/Mad2 complexes, which led to the formulation of the ''template model'', and for his contributions to the understanding of the role of the kinase

Aurora B An aurora (plural: auroras or aurorae), also commonly known as the polar lights, is a natural light display in Earth's sky, predominantly seen in high-latitude regions (around the Arctic and Antarctic). Auroras display dynamic patterns of bri ...

, Mps1 and Haspin in

. In 2008, the structure of the Ndc80 complex set the foundation of a new line of his investigations on

kinetochore A kinetochore (, ) is a disc-shaped protein structure associated with duplicated chromatids in eukaryotic cells where the spindle fibers attach during cell division to pull sister chromatids apart. The kinetochore assembles on the centromere ...

assembly and attachment to microtubules

Personal life

Musacchio spent his childhood in Rome, where he grew to be a strong supporter of

A.S. Roma ' (''Rome Sport Association''), commonly referred to as Roma (), is a professional football club based in Rome, Italy. Founded by a merger in 1927, Roma has participated in the top tier of Italian football for all of its existence, except for ...

. He has started embracing

Borussia Dortmund Ballspielverein Borussia 09 e. V. Dortmund, commonly known as Borussia Dortmund (), BVB (), or simply Dortmund (), is a German professional sports club based in Dortmund, North Rhine-Westphalia. It is best known for its men's professional foot ...

. He is married and father of two boys.

References

External links

The Department of Mechanistic Cell Biology at the Max Planck Institute of Molecular PhysiologyAll structures deposited at the PDB repository by Andrea MusacchioResearchGate profile
{{DEFAULTSORT:Musacchio, Andrea Italian biologists 1964 births Living people Scientists from Rome Heidelberg University alumni Members of the European Molecular Biology Organization Max Planck Institute directors University of Rome Tor Vergata alumni