Amdoxovir is a pharmaceutical drug that has undergone research for the treatment of

HIV/AIDS The HIV, human immunodeficiency virus (HIV) is a retrovirus that attacks the immune system. Without treatment, it can lead to a spectrum of conditions including acquired immunodeficiency syndrome (AIDS). It is a Preventive healthcare, pr ...

. It acts as a

nucleoside reverse transcriptase inhibitor Reverse-transcriptase inhibitors (RTIs) are a class of antiretroviral drugs used to treat HIV infection or AIDS, and in some cases hepatitis B. RTIs inhibit activity of reverse transcriptase, a viral DNA polymerase that is required for replication ...

(NRTI). The drug was discovered by

Raymond F. Schinazi Raymond F. Schinazi (born 21 March 1950) is an Egyptian organic medicinal chemist. He is the Frances Winship Walters Professor of Pediatrics at Emory University. He has expertise in antiviral agents, pharmacology, and biotechnology. His research ...

(

Emory University Emory University is a private university, private research university in Atlanta, Georgia, United States. It was founded in 1836 as Emory College by the Methodist Episcopal Church and named in honor of Methodist bishop John Emory. Its main campu ...

) and C.K. Chu (

University of Georgia The University of Georgia (UGA or Georgia) is a Public university, public Land-grant university, land-grant research university with its main campus in Athens, Georgia, United States. Chartered in 1785, it is the oldest public university in th ...

) and developed by RFS Pharma. Amdoxovir was in advanced

Phase II clinical trial The phases of clinical research are the stages in which scientists conduct experiments with a health intervention to obtain sufficient evidence for a process considered effective as a medical treatment. For drug development, the clinical phases ...

s around 2010. In 2013, a Phase II trial was terminated and another was withdrawn before it started. No further studies appear to have been done.

References

Nucleoside analog reverse transcriptase inhibitors Purines Dioxolanes Experimental antiviral drugs Hydroxymethyl compounds {{Antiinfective-drug-stub