Altropane (O-587, IACFT, 2β-carbomethoxy-3β-(4-fluorophenyl)-''N''-((E)-3-iodo-prop-2-enyl)tropane) is a phenyltropane derivative which acts as a potent

dopamine reuptake inhibitor A dopamine reuptake inhibitor (DRI) is a class of drug which acts as a reuptake inhibitor of the monoamine neurotransmitter dopamine by blocking the action of the dopamine transporter (DAT). Reuptake inhibition is achieved when extracellular dop ...

and long-acting

stimulant Stimulants (also known as central nervous system stimulants, or psychostimulants, or colloquially as uppers) are a class of drugs that increase alertness. They are used for various purposes, such as enhancing attention, motivation, cognition, ...

drug. It has mainly been used as the ¹²⁵I radiolabelled form for mapping the distribution of

dopamine transporter The dopamine transporter (DAT, also sodium-dependent dopamine transporter) is a membrane-spanning protein coded for in humans by the ''SLC6A3'' gene (also known as ''DAT1''), that pumps the neurotransmitter dopamine out of the synaptic cleft ba ...

s in the brain, and consequently this has led to its development as a potential diagnostic tool for early detection of

Parkinson's disease Parkinson's disease (PD), or simply Parkinson's, is a neurodegenerative disease primarily of the central nervous system, affecting both motor system, motor and non-motor systems. Symptoms typically develop gradually and non-motor issues become ...

. It is also being investigated for potential use in the diagnosis and treatment of

attention deficit hyperactivity disorder Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterised by symptoms of inattention, hyperactivity, impulsivity, and emotional dysregulation that are excessive and pervasive, impairing in multiple con ...

(ADHD).

References

Tropanes Dopamine reuptake inhibitors Medical imaging Neuroimaging Organoiodides {{nervous-system-drug-stub