An allergoid is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respon ...
that has been modified for use in desensitisation protocols, or for induction of oral/sublingual tolerance. The allergoid sustain the linear
epitopes recognized by the
MHC-
TCR
TCR may stand for:
Arts and entertainment
* ''TCR'', the musical project of Robin Moulder and TC Smith
* "TCR", a single by Prolapse
* The Comic Reader, a comics news-fanzine 1961–1984
Businesses and organizations
* TCR (record label), or Thur ...
cell-present systems (keeps the
immunoreactivity
An immunoassay (IA) is a biochemical test that measures the presence or concentration of a macromolecule or a small molecule in a solution through the use of an antibody (usually) or an antigen (sometimes). The molecule detected by the immunoassay ...
) but has less reaginic epitopes (less
allergenicity). The elaboration of allergoids through the polymerization of native allergens is performed since some decades by application of glutaraldehyde or formaldehyde. Allergoids may also be produced by genic recombination. Recently it was introduced the production of allergoids by polymerization through the microbial
transglutaminases.
See also
*
Allergen immunotherapy
Allergen immunotherapy, also known as desensitization or hypo-sensitization, is a medical treatment for environmental allergies, such as insect bites, and asthma. Immunotherapy involves exposing people to larger and larger amounts of allergen in ...
References
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Proteins